pellicle
Professional Dingbat, Guru and Merkintologist
Hi again Tommyboy
its true (just ask Skigirl or GymGuy or even Dick ... )
well I don't have any clear ideas, but issues like donor age and appropriate sizing (finding a donor with the right diameter for your needs) will make it harder. I recall waiting for something like 3 months before I got the call of "you're coming in now".
They are really good, and IMO the current generation machines work even better than the earlier ones. For instance I use a Coaguchek XS which has a different method of operation to measure the coagulation than the older Coaguchek S does.
I recently posted this thread here on this forum about a proper comparison between a commercial coagumeter and the Coaguchek XS. I suggest you read that, and you can see that the results are good compared even to labs.
Tons
I suggest that you consider starting with a cup of tea and going through this presentation at the May, while about valve selection he makes some references to coagulation studies and how that effects the stats.
http://mayo.img.entriq.net/htm/MayoPlayer1.html?articleID=4071
also, keep in mind that most of the data collected about warfarin (aka Marevan / Coumadin) is from people who are in very different demographic groups. They do not distinguish data between elderly and infirm VS young and healthy. The reality is however that the vast majority of people on warfarin are already ill and or elderly ... the vast majority are not on it for aortic valves.
A quote from the Mayo presentation from the meta-analysis review done by the Mayo
Then some direct references:
http://www.thelancet.com/journals/l...6(06)68139-7/abstract?version=printerFriendly
Self-monitoring of oral anticoagulation: a systematic review and meta-analysis
time in theraptuic INR range is a key issue to avoiding negative outcomes. By self managing, my INR was 98% in range in the last 2 years.
next
http://web.clas.ufl.edu/users/msscha/mtmcc/meta_analysis_coumarin_selfmgt.pdf
Self-management of oral anticoagulant therapy: A systematic review and meta-analysis
then
http://www.aafp.org/afp/2011/0801/p266.html
Self-Monitoring and Self-Management of Anticoagulation Therapy
Its interesting to read the notes from the Author in the above review
and in particular about why people may not self monitor or self manage
Yet it is the General Practitioner who often gives the worst results: This study compares a specialist AntiCoagulation clinic to GP Medicare management:
http://www.ncbi.nlm.nih.gov/pubmed/9701098
No wonder GP's think Warfarin is bad, look at their results!
( ... and no wonder I want to manage myself!)
There are studies revealing that self management and self measuring can further improve the results over a specialist AC clinic in the hands of patients who are trained and rigorous.
sorry for such a long answer, but your questions seemed to indicate you wanted details.
glad I can helpthank you so much for your help and sharing your experience....I am really impressed that one can still do all of these great things when on coumadin/warfarin and
its true (just ask Skigirl or GymGuy or even Dick ... )
Can I just ask about a couple of things that you mentioned:
1) Only one of the surgeons mentioned Homografts to me. But they seem like a really good idea, i.e it seems to last longer in young adults than tissue valves, but they seems to have gone out of fashion. Does anyone have any idea why that happened maybe other than scarcity?
well I don't have any clear ideas, but issues like donor age and appropriate sizing (finding a donor with the right diameter for your needs) will make it harder. I recall waiting for something like 3 months before I got the call of "you're coming in now".
2)Are the machines that you mentioned for INR managment really so reliable?
[I.e. I reckon that even if you are off by .3 and the machine says 2, when it is 1.7 could be risky?]
They are really good, and IMO the current generation machines work even better than the earlier ones. For instance I use a Coaguchek XS which has a different method of operation to measure the coagulation than the older Coaguchek S does.
I recently posted this thread here on this forum about a proper comparison between a commercial coagumeter and the Coaguchek XS. I suggest you read that, and you can see that the results are good compared even to labs.
3)I am really interested in academic material on these issues. I.e. are there any studies that show that self-management leads to risks that are three times lower as you say?
Tons
I suggest that you consider starting with a cup of tea and going through this presentation at the May, while about valve selection he makes some references to coagulation studies and how that effects the stats.
http://mayo.img.entriq.net/htm/MayoPlayer1.html?articleID=4071
also, keep in mind that most of the data collected about warfarin (aka Marevan / Coumadin) is from people who are in very different demographic groups. They do not distinguish data between elderly and infirm VS young and healthy. The reality is however that the vast majority of people on warfarin are already ill and or elderly ... the vast majority are not on it for aortic valves.
A quote from the Mayo presentation from the meta-analysis review done by the Mayo
another study showing TIR for UC vs PSM showed
PSM was in range 78% and total related events dropped from 4.7% (UC) to 2.9% (PSM)
It showed also that PST reduced the bleed complications from 11% to 4.5% and Thromboembolic from 3.6% to 0.9%
UC = Usual Care
PSM = Patient Self Monitoring
PST = Patient Selft Testing
Then some direct references:
http://www.thelancet.com/journals/l...6(06)68139-7/abstract?version=printerFriendly
Self-monitoring of oral anticoagulation: a systematic review and meta-analysis
We identified 14 randomised trials of self-monitoring:
pooled estimates showed significant reductions in thromboembolic events (odds ratio 0·45, 95% CI 0·30—0·68),
all-cause mortality (0·61, 0·38—0·98),
and major haemorrhage (0·65, 0·42—0·99).
...
Trials of combined self-monitoring and self-adjusted therapy showed significant
reductions in thromboembolic events (0·27, 0·12—0·59) and death (0·37, 0·16—0·85),
but not major haemorrhage (0·93, 0·42—2·05).
...
11 trials reported improvements in the mean proportion of INR in range.
time in theraptuic INR range is a key issue to avoiding negative outcomes. By self managing, my INR was 98% in range in the last 2 years.
next
http://web.clas.ufl.edu/users/msscha/mtmcc/meta_analysis_coumarin_selfmgt.pdf
Self-management of oral anticoagulant therapy: A systematic review and meta-analysis
Ten trials with a total of 2724 patients were included.
Two of the trials could be classified as high quality trials.
.. self-management was associated with a reduced risk of
death (relative risk (RR)=0.48, 95% confidence interval (CI) 0.29-0.79, p=0.004),
major complications (RR=0.58, 95% CI 0.42-0.81, p=0.001)
and with increasing time within therapeutic INR target range
(weighted mean difference=6.53, 95% CI 2.24-10.82, p=0.003).
then
http://www.aafp.org/afp/2011/0801/p266.html
Self-Monitoring and Self-Management of Anticoagulation Therapy
We identified 18 randomized trials (4,723 participants).
Pooled estimates showed significant reductions in
thromboembolic events (RR = 0.50; 95% confidence interval [CI], 0.36 to 0.69)
and all-cause mortality (RR = 0.64; 95% CI, 0.46 to 0.89).
Trials of self-management showed significant reductions in
thromboembolic events (RR = 0.47; 95% CI, 0.31 to 0.70)
and all-cause mortality (RR = 0.55; 95% CI, 0.36 to 0.84);
Trials of self-management alone showed significant reductions in thromboembolic events
(RR = 0.47; 95% CI, 0.31 to 0.70)
and all-cause mortality (RR = 0.55; 95% CI, 0.36 to 0.84);
self-monitoring did not (thrombotic events RR = 0.57; 95% CI, 0.32 to 1.00; mortality RR = 0.84; 95% CI, 0.50 to 1.41).
Self-monitoring significantly reduced major hemorrhages (RR = 0.56; 95% CI, 0.35 to 0.91)
whereas self-management did not (RR = 1.12; 95% CI, 0.78 to 1.61).
Twelve trials reported improvements in the percentage of mean INR measurements in the therapeutic range.
Its interesting to read the notes from the Author in the above review
Authors' Conclusions: Compared with standard monitoring, patients who self-monitor or self-manage can improve the quality of their oral anticoagulation therapy. The number of thromboembolic events and mortality were decreased without increases in harms.
and in particular about why people may not self monitor or self manage
However, self-monitoring or self-management was not feasible for up to one-half of the patients requiring anticoagulant therapy. Reasons included patient refusal, exclusion by their general practitioner, and inability to complete training.
Yet it is the General Practitioner who often gives the worst results: This study compares a specialist AntiCoagulation clinic to GP Medicare management:
http://www.ncbi.nlm.nih.gov/pubmed/9701098
btw ... INR > 5 is a significantly high risk for a brain bleed if fell over for instance.lower-range anticoagulation had fewer international normalized ratios greater than 5.0 (7.0% vs 14.7%), spent more time in range (40.0% vs 37.0%), and spent less time at an INR greater than 5 (3.5% vs 9.8%).
and so as you'd expect... had more INR within range (50.4% vs 35.0%), had fewer INR less than 2.0 (13.0% vs 23.8%), and spent more time within range (64.0% vs 51.0%).
... had lower rates (expressed as percentage per patient-year) of significant bleeding (8.1% vs 35.0%), major to fatal bleeding (1.6% vs 3.9%), and thromboembolic events (3.3% vs 11.8%); ... a lower mortality rate (0% vs 2.9%; P= .09). Significantly lower annual rates of warfarin sodium-related hospitalizations (5% vs 19%) and emergency department visits (6% vs 22%)
... reduced annual health care costs by $132,086 per 100 patients. Additionally, a lower rate of warfarin-unrelated emergency department visits (46.8% vs 168.0%) produced an additional annual savings in health care costs of $29 72 per 100 patients.
No wonder GP's think Warfarin is bad, look at their results!
( ... and no wonder I want to manage myself!)
There are studies revealing that self management and self measuring can further improve the results over a specialist AC clinic in the hands of patients who are trained and rigorous.
sorry for such a long answer, but your questions seemed to indicate you wanted details.