I went to see it with our two kids and their spouses (before reading this thread) just to be a part of the group outing. To be fair, it was not a movie I would have picked on my own. For me it was an ear splitting, eye wrenching assault of the nervous system.
My son was the only one of the five of us realized that the final battle might have been more of a rescue mission than a crazed attack. Lately I have seen a few movies where I thought the director got so carried away with fantastic special effects that the plot was overwhelmed. To me, the best movies are the ones that take the time to give you reason to care about the thoughts and feelings, of the characters. I couldn't help but notice that the death of the dog created a greater emotional impact than anything else in the movie. I think that was because we didn't really have much basis to care about the main character. There were a few moments to show he once had a family he cared about, and was looking for a cure to this horrible disease. This was a start, but, for me, it wasn't enough to draw me into his life, decisions or feelings.