question on advice I was given

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The INR drop is probably because the body WANTS to have an INR of 1.0. Given the opportunity, it probably works with the Vitamin K before it is fooled by Warfarin. The effect of REAL Vitamin K in the body may be faster than it is for Warfarin (probably because the body knows how to USE Vitamin K for making the INR lowering materials and other things that the body needs.) Warfarin is referred to as a Vitamin K Agonist (VKA), so fools the body into treating it as if it WAS Vitamin K, but is not converted into the coagulation regulating materials -- perhaps it also takes longer for the liver to process it, so this is the reason it can take 3 or more days for the full effect of a dose to be realized.

(It looks like I've got to get a book with a chapter or two on Vitamin K, VKAs, and how they work, so I'm not just speculating about why Vitamin K produces effects more rapidly than Warfarin)
 
I believe the correct term is Vitamin K Antagonist (NOT Vitamin K Agonist).

It is my (non-professional) understanding that the reason that vitamin K (or lack thereof) takes time to act is that it is a secondary reaction that controls the coagulation factors in the blood.

'AL Capshaw'
 
Al, I double checked, and you're right - it's Vitamin K Antagonist.

I'm looking into why Vitamin K acts more quickly than Warfarin, just out of curiosity. Thanks for the correction to what VKA stands for.
 
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