Mechanical vs Tissue - need help deciding

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" A study of Italian patients concluded that rs2108622(T;T) patients require 5.49 mg/day of warfarin versus 2.93 mg/day for (C;C) patients. Analysis of variance indicates that about 7% of mean weekly warfarin dose variance is explained by CYP4F2 genotype. "
cool ... thanks for that link :)

to my mind however knowing his can really only help the commencement of warfarin, for the simple formula is "test INR and dose with the intention to keep INR target = [insert your target], adjust as needed with prudence"

Oh, and for anyone reading that link:
SNP = Single nucleotide polymorphisms, frequently called SNPs (pronounced “snips”), are the most common type of genetic variation among people. Each SNP represents a difference in a single DNA building block, called a nucleotide.
(from a quick google cos its been a while and I wanted to check before I spoke ...err wrote)
 
cool ... thanks for that link :)

to my mind however knowing his can really only help the commencement of warfarin, for the simple formula is "test INR and dose with the intention to keep INR target = [insert your target], adjust as needed with prudence"

Oh, and for anyone reading that link:
SNP = Single nucleotide polymorphisms, frequently called SNPs (pronounced “snips”), are the most common type of genetic variation among people. Each SNP represents a difference in a single DNA building block, called a nucleotide.
(from a quick google cos its been a while and I wanted to check before I spoke ...err wrote)
Yes, I agree knowing you're likely to be sensitive to warfarin by checking your genotypes is only going to be of benefit when you begin taking it...so as not to overdose initially (which is what happened to me in the hospital, as they loaded me with the standard 4-5mg/day dosage, and i went over INR 4)

What has worried me a bit after reading this thread is Zelic's comment: " I decided to check anyway and found out I did have this variant in the homozygous form - 2 copies of the defective gene. With that I looked up the very few articles available and found that even when the INR is in range there is a 2+ fold incidence of high-risk bleeding events when having just one of these variant genes.":oops:

Even when you're in range...if you have these gene variants you've got a higher risk of a nasty bleeding event ? Is this true
 
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(which is what happened to me in the hospital, as they loaded me with the standard 4-5mg/day dosage, and i went over INR 4)

well happily that's not dangerous (and why they start in low) but none the less I bet they didn't know what to do.

I'd say LOL, but seriously these guys should have some training .... right?

Even when you're in range...if you have these gene variants you've got a higher risk of a nasty bleeding event ? Is this true
I don't know and until you noted it out I'd missed that
 
if you mean the cowboy practice of over inflating a balloon via catheter to widen the gap to have a broken shell of the frame of the previous valve to allow valve in valve, then yes.

Do you really want a squeezbag (the heart) to have a broken sharp edged hunk of plastic in there?

Yep, that's the technique, and if Allen recommends TAVR (which I believe he will) he'll probably throw this option in there. You'll note that this procedure requires high pressure to fracture the ring, which adds a lovely element of risk, nicht wahr?

Anyway, I'm scheduled for a cardiac cath this week, followed by a CT scan and a consult with the doc early next month, in which he'll tell me whether I "qualify" for TAVR or not. So, we'll see. From an "ease of use" perspective, TAVR seems like a good option until that sucker fails. OTOH, I'm really not crazy about OHS and anti-coagulation, but I've made my peace with it if it happens.

At what point does an amateur (however well-informed) disagree with the expert?
 
At what point does an amateur (however well-informed) disagree with the expert?
Well the surgical guidelines are there to read. If the surgeon is not recommending following the guidelines then the surgeon is offering an opinion and should justify why with sound evidence.

If the amateur has been informed of the options then that's where the word "consent" comes into "informed consent"

Remember, do not confuse the capacity of the surgeon and skills with their being a human with biases. So this is why informed patient consent is key. Further don't down play the capacity of people on this forum to have a very good set of well recognised informational sources and personal experiences.

So lets first look at the guidelines (these are not current but current hasn't changed much)
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the second last point is interesting, for if you pick a bioprosthesis and have the 'vision' of getting a TAVR later make sure you do your sums on what is a reasonable life expectancy for your age and then ask yourself this: "would you be then in the position of being at high risk patient when you've reached the inevitable end of the bioprosthesis then valve in valve TAVR Structural Valve Degradation (SVD) road?"

worth pondering that.

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read those carefully and I would personally ask why they are ordered like they are.

Next lets look at this article:
https://www.ahajournals.org/doi/10.1161/JAHA.120.018506
note what that is and who publishes it

Within that it they concern themselves with the degeneration of bioprosthetic valves. They make the case right up front that there are two choice stems: mechanical (MHV) or tissue (BHV)

the following quotes from that are telling (I'll bold those):

Valve replacement surgery is the first‐line therapy for patients with valvular heart disease. In such treatment modality, a dysfunctional native valve is replaced by an artificial one, which can be a mechanical heart valve (MHV) or a bioprosthetic heart valve (BHV). MHVs are made of pyrolytic carbon, various polymers, and metal alloys, whereas BHVs represent valve substitutes that can be of 3 types: (1) chemically stabilized tissues of animal origin (xenografts), (2) valves obtained from cadavers or live donors during heart transplantation (homografts), or (3) patients' own valves (autografts) transplanted from one position to another. Both MHVs and BHVs have their advantages and disadvantages.1, 2, 3 MHVs are durable yet highly thrombogenic, which necessitates life‐long use of anticoagulants. In contrast, BHVs do not require anticoagulant therapy and demonstrate excellent hemodynamic properties similar to those of native valves; nonetheless, their durability is limited because of inevitable structural valve degeneration (SVD), a dangerous condition eventually requiring redo valve replacement, a major surgical intervention.4, 5

SVD is an irreversible process

then:

Cyclic Loading as a Major Determinant of BHV Mechanical Degeneration
In heart valves, hemodynamic load is of cyclic nature. On average, native valves undergo ≈600 million cycles of opening and closing during 15 years of operation and ≈3 billion cycles during a lifetime.43 Cyclic stress, derived from the combination of stretching, flexure, and shear, may inflict delamination of the leaflets, leading to calcification and eventually resulting in valve failure.

short view: leather wears out

Throughout that article they make points like:
The durability of both xenografts and homografts also depends on host factors. For example, young age of graft recipient is one of the most significant risk factors determining early SVD onset, whereas patients >60 years of age often do not outlive the durability of BHVs because of relatively low life expectancy after valve surgery.

remember these are not "MY OPINIONS" they are those of THE ACCREDITED EXPERTS in the field. I just happen to have been informed by them.

So when someone here (usually older with a vested interest in a bioprosthetic) says "we're all just patients" or "nobody here is a doctor*" it is intended to discredit person presenting evidence they found informative ... this is also known as "shoot the messenger". I can only think their reason is to put more people on "their team"

Frankly I've been on both teams and I don't care nor will it effect me which team you pick. My responsibility (to myself having been through this and having been young and still not yet 60) is to present information to you to assist your process of becoming "an informed patient"

Best Wishes
*(not to mention some of us here ARE doctors)
 
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Thanks, pellicle, for this information. I do have the ACC/AHA Guidelines you reference, so I'll revisit that in more detail.

I'm almost 68, so my decision involves trying to differentiate the limitations of valve types, and the risks of present and future surgery, with life expectancy--which, from everything I've read, decreases as a result of AVR. The latter is the unknown factor, but it's a key determinant in which valve option to choose.

BHV is clearly the easier route, assuming I croak before the valve degenerates. MHV would certainly eliminate the potential for reoperation, but even there life expectancy at my age after AVR is around 15 years. Either way, it would appear, I don't have a lot of time left on the planet. One thing's for sure, I anticipate a lengthy (and difficult) discussion with my spouse and surgeon.

Oh, happy day.
 
When you read about OHS for age 85 and up the outcomes are still generally very positive. I did not find my open heart surgery for a tissue valve that bad really. I am in week 5 post op and walking a mile a day. Don’t use the chance of having a re-surgery in your 80’s as the only criteria for choosing a mechanical oval valve. The operation and recovery is not that long really. Also the newer tissue valves allow for a more simpler TAVR if elected down the road. To each his own.
 
One thing's for sure, I anticipate a lengthy (and difficult) discussion with my spouse and surgeon.

You are approaching the decision correctly, with lots of thought, due diligence and discussion. There are a lot of aspects to consider and, as you note, it can be a difficult choice to make- each choice having pros and cons.

Best of luck in coming to the decision that you feel good about.
 
...https://www.ahajournals.org/doi/10.1161/JAHA.120.018506
note what that is and who publishes it...remember these are not "MY OPINIONS" they are those of THE ACCREDITED EXPERTS in the field. I just happen to have been informed by them...

The paper is from a team of Russian scientists. It was written for qualified trained medical personnel, not laymen such as yourself. It is presented w/o any assessment by experts in the field. The research was sponsored by the Complex Program of Basic Research under the Siberian Branch of the Russian Academy of Sciences within the Basic Research Topic of Research Institute for Complex Issues of Cardiovascular Diseases. Certainly not a consensus paper from the American or British heart valve experts, the Cleveland Clinic, Mayo Clinic, a team of doctors from top hospitals in the world, etc. Not all "science" is equivalent and one paper is a data point not a consensus.
 
Isn’t it funny how people here talk about the present versus the future when making a case for mechanical or tissue valves yet tissue valves offer a better quality of life now considering no blood thinners needed and no noise attributed to them?
 
Isn’t it funny how people here talk about the present versus the future when
indeed its interesting. Some people spend everything they have all their earning life and end up beggard by that in their later years.

As a younger man with two heart surgeries under my belt already (at less than 30) I still cast an eye to my future and not at the expense of the present.

A common attribute in suffering shock is that you can only think about now, I have observed here that people only think about getting out of the frying pan they find themselves in ... perhaps it is that climbing out along the handle is better than jumping out into the fire.

You seem to gloss over that every discussion on this topic has at its core one choice holds promise of "resetting your condition to 15 years before ; but with the certainty that (if you don't die before this) but that your pre-surgery situation will return again to you. The other offers you an exchange of a diseased valve to one which can then be managed by a medicine into the future.

Pick what you like, live with it. I only try to inform.

PS: however humble it is my house in the countryside has allowed me to be debt free and retired early (see this term). I find life pretty good at 57 with essentially a very small chance of ever needing another operation.
 
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When you read about OHS for age 85 and up the outcomes are still generally very positive.
is this first time OHS or redo with a history of complication OHS? Because I'm sure you'll find that makes quite a difference.

If I was 85 and facing my first valve surgery I'd probably go TAVR as my first (again, at that age).
 
Isn’t it funny how people here talk about the present versus the future when making a case for mechanical or tissue valves yet tissue valves offer a better quality of life now considering no blood thinners needed and no noise attributed to them?

Weirdest advice I’ve ever seen for anything. “Hey man, why think of the future when you can be happy today!?!”

Runs counter to about any life, financial, career advice I’ve ever heard.
 
Weirdest advice I’ve ever seen for anything. “Hey man, why think of the future when you can be happy today!?!”

Runs counter to about any life, financial, career advice I’ve ever heard.
You missed the point. Those in favor of mechanical valves say they chose them because they can’t count on what’s available in the future regarding tissue valves, such as improved TAVR. They only can count on what they know now. Well you also have no way of knowing how blood thinners are going to work with your body nor if the noise of the valve will drive you bananas. Or the fact that mechanical valves are much more susceptible to bacterial infection.
 
Or the fact that mechanical valves are much more susceptible to bacterial infection.
Is that true? I've not seen the studies. Logically I would think the opposite whereby tissue becoming infected before a pure carbon surface getting infected.
Anyone have the data? Just curious.
 
is this first time OHS or redo with a history of complication OHS? Because I'm sure you'll find that makes quite a difference.

If I was 85 and facing my first valve surgery I'd probably go TAVR as my first (again, at that age).

I agree. I was faced with this choice two years ago when an Aortic aneurism was found and my cardio suggested surgery to repair it......which would have required replacing my old mechanical valve along with the aneurism repair. I opted not to undergo that type of major OHS in my mid 80s. At my age "quality of life" becomes much more important than "quantity of life". Believe it or not, it is OK for old people to die:eek:........I read that in an AARP article a while back;).
 
excellent, and if you're 50 then you might get that or you might not. What if you don't? (or do you prefer to not see the posts here about that issue?)

Next what about 40?

Wait, maybe you didn't know that age was the single most important selection factor for the actual real durability of a valve? Do you think everyone gets that?

If you are talking about for you then great ... if you are advising "in general" then what about younger people?
https://www.valvereplacement.org/th...lacement-done-at-young-age.888330/post-912518
As I keep saying "parameters" matter. As you have no information in your bio one has to guess, but if you were born in 1955 then I'd hazzard that you would be well served by a tissue, which when it goes into SVD may be a candidate for TAVR ... I would check the table posted earlier about the candidates suitable for that.

BTW context free posts of "this is better than that" are the realm of idiots. The truth about idiocy, which is that it is at once an ethical and a cognitive failure. The Greek idios means “private,” and an idiōtēs means a private person, as opposed to a person in their public role.

I post here in my public role and you'll see I always ask for more parameters;
  • age
  • ***
  • any reasons why anticoagulants are contra indicated
perhaps you should consider moving towards advice here in your public rather than internalised discussion.
 
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