Insulin and statins causing calcification?

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LondonAndy

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My journey through AVR started over 10 years ago now, in 2014, and was needed because of severe stenosis. I don't know why I haven't thought to post this sooner, but a search of past topics doesn't seem to suggest this has been discussed, so here goes, perhaps of interest to those in the waiting room, or indeed simply for some of those who wonder why they needed a valve replaced.

After my operation, my surgeon described my diseased valve as being "as white as a piece of cauliflower", and said that it was now thought (by 2014) that the combination of insulin and statins causes calcification. By 2014 I had been on insulin for 8 years and statins for over 20 years, owing to a strong family history of cardiac issues. So this certainly seemed plausible, and some amateur Googling finds that even statins on their own are likely to cause calcification, as does insulin resistance. So as is often the case in medicine it seems, we solve one problem but cause another!
 
some amateur Googling finds that even statins on their own are likely to cause calcification, as does insulin resistance. So as is often the case in medicine it seems, we solve one problem but cause another!
Cannot comment on the insulin part. For the statins and calcification, I followed your link and the references in that article. The explanation offered is that there are 2 changes: 1) increase of calcification and the "hard" part of a plaque, 2) reduction of its soft part. So in the end the plaque becomes more stable after such remodeling. Besides the measurements, the other supporting evidence is that there was no increase of the stroke events, in spite of the increased calcification.

It's possible that there are more "dimensions" of this, and I cannot comment on the valve calcification or the insulin impact. But I guess the calcification is not always bad by itself?
 
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