Highest INR you have heard of or experienced?

[pellicle]

Hi

...my family always buy them and I used to eat many and was ready to do so..until now, can you provide more info?

What sort of information are you after?

The risk is that if you eat some that your INR may elevate. By how much will depend on unknown factors (like your genetic profile and the specifics of the mandarin).

Test and know thyself

Best Wishes

 

[pellicle]

can you provide more info?

From my blog (which I assumed you had read, but may not have)
https://cjeastwd.blogspot.com/2021/05/grapefruit-and-warfarin.html

The purpose of todays blog post is to add a little more clarity to that post and explain some of what was in that podcast interview.​

​

In that podcast Dr David Bailey mentioned in his discussion talked about enzymes in the gut and the changes of bioavailability. If you just listened to that you may be a bit confused about what's actually going on with this bitter "fruit" and warfarin because you may think to yourself​

​

"but wait, warfarin is highly bioavailable, so how does this influence me"​

and that's because there is another issue which Dr Bailey did not cover and that's enzymes in the liver. Specifically thats Cytochrome P450; which as I've discussed elsewhere essentially clears toxins out of the blood (and warfarin is actually a toxin). So the active ingredient in this nasty bitter fruit is furanocoumarins (which you can read about here) that interfere with P450. This is important because if you think about it if you put something into your body where does it go? Does it stay there or go away? Some things are used to build you (like calcium in your bones) and some things are used to fuel you (like sugars) and others are deemed bad for you by the body and are disposed of.​

HTH

 

[carolinemc]

Pellicle,

I was reading this older thread and i saw you mentioned Spanish Mandarins”, i knew about grapefruit (this fruit interacts with so many things) but your mention of the mandarins got me thinking. I live in Spain for a good part of the year (got here a couple weeks ago) my family always buy them and I used to eat many and was ready to do so..until now, can you provide more info? I couldn’t find in the link you had attached but I may have missed it.

Thanks

Any grapefruit can interact with Warfarin. Sad but true.

 

[dick0236]

Any grapefruit can interact with Warfarin. Sad but true.

Several foods and drinks can or do interact with Warfarin. I recently found that "clementines"(little oranges) interfere with my INR if I consume a lot of them. I eat half a Grapefruit a few times each month, even tho that might affect my INR a little. My experience is that almost all foods/drinks can be enjoyed in moderation.......just don't PIG OUT.

 

[Windfinder]

From my blog (which I assumed you had read, but may not have)
https://cjeastwd.blogspot.com/2021/05/grapefruit-and-warfarin.html

The purpose of todays blog post is to add a little more clarity to that post and explain some of what was in that podcast interview.​

​

In that podcast Dr David Bailey mentioned in his discussion talked about enzymes in the gut and the changes of bioavailability. If you just listened to that you may be a bit confused about what's actually going on with this bitter "fruit" and warfarin because you may think to yourself​

​

"but wait, warfarin is highly bioavailable, so how does this influence me"​

and that's because there is another issue which Dr Bailey did not cover and that's enzymes in the liver. Specifically thats Cytochrome P450; which as I've discussed elsewhere essentially clears toxins out of the blood (and warfarin is actually a toxin). So the active ingredient in this nasty bitter fruit is furanocoumarins (which you can read about here) that interfere with P450. This is important because if you think about it if you put something into your body where does it go? Does it stay there or go away? Some things are used to build you (like calcium in your bones) and some things are used to fuel you (like sugars) and others are deemed bad for you by the body and are disposed of.​

HTH

Ah ok, I had read it but not listened to the podcast. I will surely measure any time after I eat mandarins. Thanks a lot!

 

[pellicle]

I will surely measure any time after I eat mandarins

INR elevation will occur after days, and be transient. Eating one fruit is unlikely to see any changes, eating one (or more) per day for a week will. Same goes for drinking the juice, but moreso.