Julie
Juliemoon;n870736 said:
Does anyone have any info on the long term effects of coumadin therapy?
FIrstly I want to emphasise
I am not telling you what to do or making a suggestion. So to answer your questions there is no evidence (after what, 60 years of use) that coumadin has any side effects. There is one study where rats fed ten times a lethal dose or farfarin, countered with massive injections of an antidote (Vitamin K) developed problems. It would not be possible for a human to eat that much warfarin (and get litres of vitamin K injections)
If the statins that eveyone loves and the anti-depressents everyone reaches for were subject to as intense and enduring scrutiny they would be banned.
In contrast the issues of warfarin (coumadin) are quite simple and plain:
- being on warfarin may complicate some prodecures and other drug usage
- failure to monitor INR (which takes me on average 5 min per week) may leave you at greater risk of stroke or bleed
- long term recalcitrance (not taking it) can lead to a valve obstruction by a thrombus. This was a reoperation driver but now is treated with a PICC delivered therapy to disolve the clot. It is proving quite effective.
Basically noone loves warfarin because it was very poorly managed in the past (I can elaborate on that if desired) and its an extremely low profit margin drug and essentially cuts whole swathes of the medical system out of the picture.
Evidence is emerging that well managed INR will put you in no different a risk group than the normal age related population. So the bad wrap of warfarin is due to mismanagement and a section of the medical community who is uninterested / unmotivated to review their out dated views.
IF you are elderly
or if you (like mellyouttaphase) are just too irregular that you couldn't adapt to the regime of taking your pills (and they don't even HAVE to be on time, I occasionally delay mine by 6 or so hours if I'm out)
or if you are struck with sickness at the thought of hearing your own heart beat then you should pick a tissue for your own peace of mind.
Also if you are over 60 there is a chance you will kick the bucket before needing a reop because its possible that they can last 20 years. If you are under 50 then one reop is in your "cards" and if you are under 40 then two. Its up to you how you interpret the risks of surgery, surgeons don't like to play that up (although some do as the one I have mentioned in my blog post ... PM me if you want a copy of the recording of his talk that was published on the Mayo Clinic, it has been removed because SWF is no longer supported by browsers).
I originally did a Biochemistry degree (double major with Microbiology) and I've researched the shitter out of this ... and hand on heart that's the bottom line as I see it and a few years here has not changed that with any new evidence.
People love to counter that having a mechanical valve is no certainty of avoiding a reoperation. That is true however having a tissue valve in certain age groups is a certainty that you will need a reoperation. PLUS almost every case where a reoperation would be needed for a mechanical valve (predominately aortic aneurysm) then such would also drive the reoperatoin of ANY valve.
The above points are not in dispute with any surgeon or cardiologist. I encourage you to print them out and take them and ask questions. Some may lean one way or another but the points above stand.
dick0236 , any sign of dementure yet?
Lastly with respect to K2 there are a number of studies but they are quite inconclusive at this stage. The major interest I see emerging is that taking K2 may make your INR more stable if you are one who's INR is unstable. I was an unstable INR "client" until I gave my clinic the bird and took management under my own roof. This has meant that I'm in range 97% of the time (almost unheard of at a clinic who often boast 80%) and I have total freedom of movement. I can travel as I please and just take my coagucheck with me.
Here I am in Finland after having sold my house in Australia.
Best Wishes