I had my first lab visit today (finally--what led up to it was something of a nightmare) and it was a tad low (1.7; they want it between 2.5 and 3.5), so the tech changed my regimen (which was 1 mg. every night at 5 pm) to 3 mgs. tonight, 2 tomorrow, and a couple of other fluctuations over the next week until I test again next Wednesday.
She suggested only two things about time: that I take it when I don't take other meds, and that I take it at bedtime and take my other meds at dinner (in other words, switch when I take them) and in the morning. She'd like me to have metabolized the dose before I get tested until I'm more stable (no appetite makes eating something of a chore). I really had no idea of how complicated this was going to seem when my head's still in a muddle. The discussion here is really useful.