pellicle
Professional Dingbat, Guru and Merkintologist
So I thought this subject had come up and indeed in 2017 we have this post in a "post recovery" thread by Dreamy
https://www.valvereplacement.org/threads/a-week-after-surgery-my-story.876755/post-878689
most of the navigation in that is broken but if you progress manually you can find the discussion underneath that. You'll see that I was initially a bit skeptical that Cinnamon was the actual cause in her situation.
However it was raised again by a friend of mine (who once was a member here) when he told me that he'd found that Cinnamon was a prime suspect in his INR variability as he has Cinnamon in his coffee. Picture below is a reference for how much he puts in his coffee (that's a teaspoon)
He found this caused approximately a 1 point INR shift. I don't know how much Dreamy added to her smoothie.
So the following links may be interesting reading.
Mechanisms of Herb-Drug Interactions Involving Cinnamon and CYP2A6: Focus on Time-Dependent Inhibition by Cinnamaldehyde and 2-Methoxycinnamaldehyde
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7543486/
the importance of the gene CYP2A6
CYP2A6 - an overview | ScienceDirect Topics
https://www.sciencedirect.com/topic...a major role,, pilocarpine, and valproic acid
lastly a report from the literature
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6726349/
Interesting stuff ... so now I have another SHTF solution (to supplement red wine and tomato and turmeric based goat curries). Cinnamon coffee.
I'm going to do an experiment on this (as tomorrow is INR day)
Best Wishes
https://www.valvereplacement.org/threads/a-week-after-surgery-my-story.876755/post-878689
most of the navigation in that is broken but if you progress manually you can find the discussion underneath that. You'll see that I was initially a bit skeptical that Cinnamon was the actual cause in her situation.
However it was raised again by a friend of mine (who once was a member here) when he told me that he'd found that Cinnamon was a prime suspect in his INR variability as he has Cinnamon in his coffee. Picture below is a reference for how much he puts in his coffee (that's a teaspoon)
He found this caused approximately a 1 point INR shift. I don't know how much Dreamy added to her smoothie.
So the following links may be interesting reading.
Mechanisms of Herb-Drug Interactions Involving Cinnamon and CYP2A6: Focus on Time-Dependent Inhibition by Cinnamaldehyde and 2-Methoxycinnamaldehyde
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7543486/
the importance of the gene CYP2A6
CYP2A6 - an overview | ScienceDirect Topics
https://www.sciencedirect.com/topic...a major role,, pilocarpine, and valproic acid
lastly a report from the literature
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6726349/
An 80-year-old man on dabigatran with a known history of NV-AF presented with a 1-day history of haematemesis and black stool which began 3 days after he had started taking a boiled mixture of ginger and cinnamon. The patient was hypotensive and treated as a case of gastrointestinal bleeding and haemorrhagic shock. Despite continuous aggressive resuscitation measures including administration of a reversal agent for dabigatran, we were unable to control bleeding and the patient died within 24 hours. The interaction of ginger and cinnamon with dabigatran led to fatal bleeding.
Interesting stuff ... so now I have another SHTF solution (to supplement red wine and tomato and turmeric based goat curries). Cinnamon coffee.
I'm going to do an experiment on this (as tomorrow is INR day)
Best Wishes
