Great article on Vitamin K Supplementation and Anticoagulation Control

[TheGymGuy]

I was looking for this article and found it. There are more out there: http://www.clinicalcorrelations.org/?p=4615

Just saying that what you guys preach is the very right thing to do. Doze your diet and having the Vit. K in it will actually make INR more stable even with Vit. K intake fluctuations.

EDITED BELOW AFTER MORE RESEARCH:

• http://www.ncbi.nlm.nih.gov/pubmed/16305294 - Low-dose vitamin K to augment anticoagulation control. Basically, talks about Vit. K supplementation regulating INR in unstable patients.
• http://clinicaltrials.gov/ct2/show/record/NCT00794755 - Low Dose Supplementation to Improve Anticoagulation Control With Oral Vitamin K as an Adjuvant to Warfarin Therapy (LOCK). This was a study which went on for 3 years. I am looking for published results but am still unable to find them. If anyone sees the results to this, please update this thread.
• http://bloodjournal.hematologylibrary.org/content/109/6/2419.full.html - Vitamin K supplementation can improve stability of anticoagulation for patients with unexplained variability in response to warfarin. I liked this write up as well. I like that they show improvements in majority of the control group.
• http://circ.ahajournals.org/content/120/12/1115.full - Improved Oral Anticoagulation After a Dietary Vitamin K–Guided Strategy. A Randomized Controlled Trial.
• http://www.jfponline.com/Pages.asp?AID=6073 - Does adding vitamin K to warfarin improve anticoagulation control? Yes. This is just a summary article.
• http://www.lef.org/magazine/mag2007/jun2007_report_vitamink_01.htm - Stabilizing Anticoagulant Therapy—While Protecting Cardiovascular and Bone Health. This is a fun report which reads pretty easy.

Hope it helps some of you. I have started my multi-vitamins that also have Vit. K in them. Will keep on updating my INR in another thread, but all this research looks very promising.



EDIT: Linking up 3 articles that I started which all talk about Vitamin K and/or Coumadin/Warfarin
1. Vitamin K links to USDA.gov: http://www.valvereplacement.org/forums/entry.php?61-Vitamin-K-links-to-USDA-gov
2. Great article on Vitamin K Supplementation and Anticoagulation Control: http://www.valvereplacement.org/for...K-Supplementation-and-Anticoagulation-Control
3. How Warfarin works - good read: http://www.valvereplacement.org/forums/showthread.php?40393-How-Warfarin-works-good-read

 

[carolinemc]

Thanks for sharing this with us. There are those of us who worry about the vitamin K problem. Hugs for today.

 

[sarahsunshine]

Thanks for the summary paper. I've read severeal similar peer reviewed journal articles saying the same thing (which I can't site right now).

Makes sense really. If you have only a little vit K in yoru body, then you take low dose warfarin. small change in vit K will affect dose of warfarin.

If you have high vit K to the point where your vit K stores are full, then if you have variation, your body's stores keep your levels relatively stable. Added benefits are the extra viatmins and minirals you get from leafy greens, and decreased chance of side effects (arterial calcification being a big one).

Always need to look at the big picture, but fortunately more people are getting it right these days.

 

[TheGymGuy]

I want to add some more resources as I am actively researching this topic right now.

• http://www.ncbi.nlm.nih.gov/pubmed/16305294 - Low-dose vitamin K to augment anticoagulation control. Basically, talks about Vit. K supplementation regulating INR in unstable patients.
• http://clinicaltrials.gov/ct2/show/record/NCT00794755 - Low Dose Supplementation to Improve Anticoagulation Control With Oral Vitamin K as an Adjuvant to Warfarin Therapy (LOCK). This was a study which went on for 3 years. I am looking for published results but am still unable to find them. If anyone sees the results to this, please update this thread.
• http://bloodjournal.hematologylibrary.org/content/109/6/2419.full.html - Vitamin K supplementation can improve stability of anticoagulation for patients with unexplained variability in response to warfarin. I liked this write up as well. I like that they show improvements in majority of the control group.
• http://circ.ahajournals.org/content/120/12/1115.full - Improved Oral Anticoagulation After a Dietary Vitamin K–Guided Strategy. A Randomized Controlled Trial.
• http://www.jfponline.com/Pages.asp?AID=6073 - Does adding vitamin K to warfarin improve anticoagulation control? Yes. This is just a summary article.
• http://www.lef.org/magazine/mag2007/jun2007_report_vitamink_01.htm - Stabilizing Anticoagulant Therapy—While Protecting Cardiovascular and Bone Health. This is a fun report which reads pretty easy.

Hope it helps some of you. I have started my multi-vitamins that also have Vit. K in them. Will keep on updating my INR in another thread, but all this research looks very promising.

 

[Cris N]

I take a multivitamin with 25 mcg vit k and a supplement of 100 mcg vit. k. To be honest, this is the best way for me to keep my INR stable.

 

[coffeelover]

Interesting articles.Thanks for sharing!

 

[normofthenorth]

"Hook" also made a convincing case -- mostly around http://www.valvereplacement.org/for...3-Vitamin-K2-and-Warfarin&p=525065#post525065 -- that supplementing with Vit. K2 rather than (or in addition to) the more easily available Vit. K1 (=~ "Vitamin K in general") may be especially helpful to all of us valvers, not just the mech or ACT crowd. The K1 helps to stabilize INR levels, and the K2 has direct Cardio benefits, as I recall. Warfarin/Coumadin, as a Vit. K antagonist, may decrease the beneficial effects of K2, as well as the undesireable pro-clotting effects of K1.

 

[TheGymGuy]

Bump for those that have not read this yet.

 

[TheGymGuy]

I figured, I should bump this up regularly as it has loads of useful material.

 

[TheGymGuy]

bump for reading for newer folks

 

[TheGymGuy]

A bit more links on the Warfarin/Coumadin:

This document has amounts of vitamin K in different foods: http://www.drgourmet.com/md/warfarincomprehensive.pdf
Interactions with food: http://www.ihtc.org/patient/blood-disorders/clotting-disorders/coumadin-interactions-with-food/
Reversal Protocols: https://www.mja.com.au/journal/2004...es-behalf-australasian-society-thrombosis-and
Coumadin use and Vitamin K, a study on Atrial Fib Patients: http://digitalcommons.usu.edu/cgi/viewcontent.cgi?article=1007&context=honors

 

[Protimenow]

And to think that just a few years ago, we were being warned to NOT eat anything with Vitamin K. (Remember the Coumadin Cookbook?).

I have to get more regular with my vitamin intake -- including more K (I haven't been avoiding it).

 

[Cris N]

I'm still taking Vit K supplement and am still able to stay quite consistent with my INR. For those looking for Vit K I buy mine from Puritan's Pride. Before that I got it from GNC online (my local store didn't carry it).

 

[TheGymGuy]

Bumpity-bump for new members to read.

 

[Warrick]

Bumpity bumpity bump bump ... (couldn't resist)

And happy new year!!

 

[Warrick]

Re-stumbled across this post and now I'm very curious in regards to those who take a vit K supplement as to what amount if any (in mg) you have had to increase your dose to stay in range

have had a few big peaks in the graph line over several weeks and just considering if a vit K sup might be the ticket