pellicle
Professional Dingbat, Guru and Merkintologist
I think this deserves a quick primer:
So lets look at a diagram of this (yes, its complex and shows how the large molecules involved transform after essentially triggering reactions, biochemistry is such a complex subject BTW).
Warfarin acts on the purple squares (as well as one not directly involved, and I suspect is a precursor stage) while apixaban only acts on the orange square.
So there is quite a lot happening which apixaban isn't touching.
I'm suspicious that the exact mechanisms involved in thrombus generated within the stream of blood triggered by pressure (measured in dynes) is not something which is covered by direct factor X inhibition.
*looks at the menu ... So yes, I'll have warfarin and testing thanks, over easy.
Warfarin exhibits its anticoagulation effects via the intrinsic and extrinsic pathways in the clotting cascade. This activity occurs through effects on vitamin K-dependent clotting factors (II, VII, IX, and X) and the anticoagulant proteins C and S.
(ref)So lets look at a diagram of this (yes, its complex and shows how the large molecules involved transform after essentially triggering reactions, biochemistry is such a complex subject BTW).
Warfarin acts on the purple squares (as well as one not directly involved, and I suspect is a precursor stage) while apixaban only acts on the orange square.
So there is quite a lot happening which apixaban isn't touching.
I'm suspicious that the exact mechanisms involved in thrombus generated within the stream of blood triggered by pressure (measured in dynes) is not something which is covered by direct factor X inhibition.
*looks at the menu ... So yes, I'll have warfarin and testing thanks, over easy.
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