Beta Blocker Question

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M

M&M

Hi, I was put on atenolol about 2 years ago along with mexiletene for my vt's. Anyways, I've often wondered if my beta blocker could have 'increased' my mitral valve regurgitation. I read on one web site a doctor posted that beta blockers can worsen MR. Do you know where I could get more information on this? If you believe this to be accurate. I take atenolol for my high blood pressure - but I wonder if I switched to a diuretic if perhaps my mitral valve might be less leaky and my left ventricle would decrease in size.. Just a thought.. which I know when I 'think' it tends to get me into trouble. I just have had very little luck with meds and of course now I'm wondering if this med could have made my situation worse as one doctor noted beta blockers can do this. If I discontinue - I would be curious to see if my situation got better and I would not need mitral valve surgery.

Thanks
Marilyn and **** - Runner
 
You were thinking of discussing this with your doctor, weren't you? You can't just stop beta blockers cold. There must have been a reason for putting you on it in the first place. You've got some very serious problems. Please call the doc and have a chat with him about what options you have.

Best wishes.
 
Well Nancy, now that you mention it - I did discuss it - he didn't think it was a good idea because it might increase my angina. Which I think I would rather tolerate angina than valve surgery. I've always had angina. So, I'm fairly use to it. They always run a battery of stress tests and catherizations and plaque buildup is never the culprit. I guess I'm just prone to angina - I don't think angina is a symptom of MR.. I just thought if I could find more information - regarding beta blockers and MR then maybe I could persuade him to agree with my 'thinking'...

Best Wishes
Marilyn and **** (runner)
 
Just out of curiosity I have to ask.
My wife is also taking Atenolol for her heart but she also takes Altace for her blood pressure problems and it has worked extremely well.
 
Hi Runner -

Not to nitpick, but angina isn't benign, is it? Isn't it a signal from your heart that something is wrong? Seems to me that if your heart isn't pumping efficiently (you mention MR, VT) then its own blood supply might be compromised, hence the angina.

Beta Blockers should not be stopped suddenly. They help to reduce the load on your heart . You must wean yourself off of it slowly so you don't induce abnormal rythms (or worse).

I'd be all over getting a second opinion on what is causing that angina just as much as I would for the valve condition.

Sorry if I accidentally played doctor here :)
 
Thanks Rich and Johnny for your responses. My EP doc has responded to my e-mail message and feels its unlikely that my cold hands are cold feet are side effects of the beta blocker. I don't agree. I could be wrong. I just know I can't work and FREEEEZE at the same time. I'm to uncomfortable and they won't let me turn the heat up in the office and I can't type with gloves.. Its horrible - soo I did some searching and beta blockers can give you cold hands and cold feet. My doc suggested in his e-mail that I taper myself off the drug although he's not in favor of this as he feels atenolol is one of the better drugs for me and works well with my mexilitene in keeping a lid on my ischemia and vt. Which I don't think I've noticed a vast improvement on my angina. He has suggested I wean myself off the atenolol and perhaps after a couple weeks try the atenolol again !!! Or perhaps another beta blocker or as a distant second choice a low dose of a calcium blocker. Sooo, I'm going to wean myself off and see if the freezing cold hands feet go away - if they do - then I know it was the med. Then we'll see if I need another drug at that time.

Rich your wife has found a good combination that works for her and that's what I'd like to find. There are so many different drugs on the market - if this one is making me freeezing cold - then certainly my doc and I shoud try to find an alternative.

Johnny I think your right about the angina - I've had it for years and never have I gotten an explanation for it.. Only to say perhaps its non-cardiac related !!! but the minute I want to stop my medicine - somehow the angina is definently cardiac related - so I need the med !!! I think woman are just prone to angina. They've checked everything inside me and never came up with an explanation. I do wonder if what I read is true that beta blockers can worsen the MR !!!

Thanks for your response and suggestions.

Marilyn and **** - Runner
 
Hi Runner

I was on Beta Blockers for about 4 years before my surgery. I was on Nadolol and then Corgard. I actullay felt better on them. I had cold hands and feet and did for years before my surgery. Since then, no more. Maybe it was the surgery that improved my circulation and not going of the Corgard that did it. Perhaps we'll never know. But, cold hands and freezing feet sure beat the heck out of feeling like a slug.

There is no doubt that Beta Blockers are serious business. I have posted on here before that I had some problems with them breaching the blood-brain barrier. (that's a mouthfull!). But, I knew that I needed them and the PVCs and feeling lousy were worse than the drugs.

Please don't be so afraid of the surgery that you do yourself harm by not using medicines to help you. If you can be treated medically and stave off the surgery for a while that's great. No one WANTS surgery, but the alternative is unthinkable. All in all, mine was not nearly as bad as I had imagined it would be.

I would be interested to know in what circumstances beta blockers worsened MR. It might be that it happened in people who had other chronic diseases. I know that all the medical folks say anyone with a chronic illness should not really use Ibuprofen because of the toll on the liver. But, if you have Lupus, Ibuprofen is a real life saver.
Perhaps, in your case, you can take the BB's without effect.
My "amatuer cardiologist" opinion is that the cold hands and feet are part of the valve problem and not necessarily because of the BB. I say that because I had cold hands and feet for years before I went on BB's.

But, only you and your doc can work out what is right for you.
 
Hi Mara, thanks for your post. :) You know I thought it was alittle 'strange' when I read about b-blockers making MR worse - but I saw it on another web from someone's else's post. I saw it on "The Heart Forum" - a cardiologist posted it in response to a patient post. He said: "In patients with MR, beta-blockers can actually worsen the MR and would not be considered first-line therapy by most cardiologists." But maybe that's for people who haven't had an MI and 'don't' have heart disease - maybe its for MR from another source... like rheumatic fever or something. I don't know.. I couldn't find any other place where it said it wasn't ok to take b-b for MR... I should not be so nosey and snoop into other webs and stuff.. I did find others who said that b-b gave them cold fingers and feet. So that was nice to hear - well not nice that they suffered from cold hands and feet - but nice to know its not uncommon.. I guess I'm not the only one. I'm sure my doc and I can find something else to replace it that would work for me. I went 10 years with no beta blocker - so I'm sure waiting alittle while to find just the 'right' one will be worth the effort.

I'm sorry to hear that b-blockers made you feel sluggish - I've heard they do that to people.. Sometimes the cure is worse than the disease.. and sometimes the drugs are a great benefit to many people.

I just have a bad time with drugs.. They don't agree with me and its hard to type at my desk when my fingers are freezing.. There must be a better solution. I'm sure there is.

You could be right - perhaps its my valve causing the cold hands and feet - but, one sure way to find out if its the drug is to stop it slowly and see if the symptoms go away. At least I 'think' I'm heading in the right direction.. I'm not sure my doc is to happy - but he did say I could try another drug after I wean myself off this one.. So that's good. He's a really nice doc - and I like him alot - he has the patience of a 'saint' cause meds and I don't get along.. I'll be so happy when my feet and fingers aren't freezing anymore.. :)

Thanks Mara
Have a nice weekend..

Marilyn and **** (runner)
 
Scary!

Scary!

runner, you really scared me when you posted about beta blockers possibly worsening mitral regurgitation. You wrote:
<< I saw it on another web from someone's else's post. I saw it on "The Heart Forum" - a cardiologist posted it in response to a patient post. He said: "In patients with MR, beta-blockers can actually worsen the MR and would not be considered first-line therapy by most cardiologists." But maybe that's for people who haven't had an MI and 'don't' have heart disease - maybe its for MR from another source... like rheumatic fever or something. I don't know.. I couldn't find any other place where it said it wasn't ok to take b-b for MR... >>
I have CHF/DCM. My two main issues are systolic dysfunction of the left ventricle and mitral regurgitation, both described as "moderate to severe."
The first thing the cardiologist did was put me on a beta blocker, coreg (carvedilol). It is supposed to be THE drug these days for CHF. They are titrating me up to get to the goal of 25mg twice a day. I am also being considered for mitral valve surgery. The way it was explained to me, for patients with CHF coreg is absolutely essential, for better survival chances and for dealing with symptoms.
I am one of those patients who has "idiopathic" DCM--i.e., nobody knows the cause. I do not have CAD and have had no MI's; I don't smoke, have no history of alcohol or drug abuse; no known infections; no weight problem; low cholesterol--I am a very boring person! The only "risk factor" I seem to have had was high blood pressure.
I have never had rheumatic fever (or if I have nobody ever told me).
So I would really like to know more about this beta blocker/mitral regurgitation problem if I can.
I thought I was doing so well on the beta blocker. Have been titrated up to the third level in just over a month with no bad effects I've noticed.
 
Hi Marge, You know I was really upset when I read it. I checked it out more thoroughly from some other medical people and they said: That's not TRUE.. Beta blockers are an excellent drug for MR. Butl I was still nervous and since I was getting cold hands and feet - I blamed those symptoms on my beta blocker and I asked my cardiologist if I could go off it - he didn't want me to - but reluctantly let me try - I felt awful.. I have never promoted a drug - but this beta blocker (atenolol) works very well for me. - I can't believe it worsens MR..

I think The Heart Forum response to another patient post that I read was not accurate. I certainly wouldn't go off it without my doctors knowledge. I regret that I even tried to go off it. I don't for one minute think it worsens my MR.. If your not sure - ask your doctor. I never should have read the response on that web site - it really upset me - like you I was worried.. Perhaps the responder on that web meant M??? or some other letters - but not MR.. Maybe the responder didn't realize what he had typed in..

When in doubt - ask your doctor - don't make yourself sick like I did to myslef.. I was sooo upset.. When in doubt - save yourself alot of worry and ask your doctor..

Take Care
Runner
 
runner, thanks for the reassurance.
No, I would NEVER go off a drug without talking to the doctor! Especially not this beta blocker I am taking, coreg.
One of the first things I was told when I started this process was that, just as they titrate your dosage up very very carefully, monitoring all the signs, any lowering of the dosage has to be done that way too.
 
Hi Runner,

If you did a "search" on here you may have found many of my posts on this topic.

There are some Beta Blockers that will make you feel more sluggish than others, and there are some that will also make you feel more depressed. The Lopressor family of Beta Blockers specifically has these effects.

The Lopressor family crosses the blood/brain barrier and effects the central nervous system more than the other drugs in the Beta Blocker family.

I have been on Atenolol for almost 4 years now, and I feel fine. Although, many times I think that perhaps I have just become accustomed to my Beta Blocker life style, if you catch my drift.

Beta blockers are designed to accomplish 2 functions; Lower your blood pressure, and slow your heart rate. Well, the slower heart rate slows your metabolism, of course you are gonna feel a bit more sluggish. The other thing is, you don't burn as many calories because your metabolism is slower. I can be on a treadmill at a 4.4 mph walking pace, and my pulse will not break 100! Whew... now wonder I put on a few lbs.! and to think... before I knew this I blamed the beer!

Anyway, my advice for those on Beta Blockers is to check with their doctors, especially if they take Lopressor, or one of the time release Lopressor family of drugs. Ask if they would try switching you to a different Beta Blocker to see if you feel better.

As to me researching this, 2 of my friends were on Lopressor. They switched, and felt much more energetic. Then, wham... I had to start taking a Beta Blocker. Guess what ? the doctor recommended Lopressor. I was on it for about a month, felt depressed, and based on the info from my friends and my reseach, I asked the doctor to switch to another Beta Blocker. He also verified that Lopressor does effect the central nervous system more than others due to more of it crossing the blood/brain barrier. I think doctors are just used to putting folks on Lopressor because that was the standard for so many years.

Hope this info helps arm you with questions to take to your doctor.

Happy Holidays!

Rob
 
I got a question.

I got a question.

My Ryan and I are having a bit of a disagreement about this very thing right now..... he also takes Atenolol. He just informed me that he's going to stop taking it until finals are over!! He thinks it slows him down and makes him sluggish. But when he stops taking it, it really throws him for a loop for a while! He does have high blood pressure... and the dilated stretch on his aorta!

He?s almost out of pills and wants to switch beta blockers. He says he also thinks the atenolol is responsible for an itchy rash he gets on his body. Anyone else have that problem? Is atenolol of the lopressor family?? Is Toprol XL of the lopressor family? ... that?s what I take. I?ve never had high blood pressure... but my cardio likes me on it anyway... it keeps my BP at about 100/70 taking 25 mg per day. He says lower blood pressure = less stress on the mechanical valve.

Donno what I'm gonna do with my Ryan. I told him it's time for him to call the cardio for a chat instead of me. :rolleyes: He's gonna drive me crazy!!

I get cold hands and feet too. A lot of times I can't get my heart rate over a 100 BPM either... even tho I'm sweating like crazy!!! It never goes over 120. I've just started taking half my normal dose of my beta blocker. SHHH!!!!!! Don't tell Ry!! :eek:
 
Hi Rob and Rain, You know I didn't think the beta blocker slowed me down after the first couple months. It did at the very very beginning - but I just kept pushing and pushing and well I'm still running half marathons - but I am more tired afterwards - but then I'm older tooo. I've hit some pretty big hills on the last couple half marathons. I think it does slow down my metabolism as I gained about 10 pounds since I've been on it.. Not so bad anymore - I seem to have stabilized with my weight.. Of course my pants are tight and I keep trying to get the extra 10 pounds off - but I can't do it.. I think maybe some of that extra weight is menopause for me.. :-(

But I did get the 'itchies' when I first went on atenolol - no rash - but wicked itchy - and I became so bitchy - it was like I was laying in a bed of insulation. So I stopped taking the atenolol. Then about 3 weeks later I got shocked from my ICD when I was running in some road races - and my doc was on vacation - so I decided well maybe I better go back on the atenolol.. and because I was so upset about my shocks and the thoughts of being itchy again - I remember my doc telling me to drink a glass or two of wine a day - that it was good for me.. I hadn't done it - but I thought maybe now is a good time... So, I went to the bar with my husband and said I need a glass of red wine - the bartender looks at me and thinks I'm nuts and so he asks - what kind? I didn't even know any names of red wine.. But he gave me one - it tasted awful - about the third sip - all my itchies were gone. Just like THAT !!! I was quite happy - then about 24 hours later the itchies came back - so I had a glass of wine again - and puff the itchies went away again... I said you know there is something in this red wine that takes my itchies away. Been drinking a glass of wine ever since.. Of course when the day comes that I get my new and improved mitral valve and I have to go on coumadin - I don't want to stay in the habit of drinking wine. Its only been a year or so since I've been doing this. I hate the taste of wine - I put lots of ice in it and it tastes just awful - but I have NO ITCHIES !!!! I think my doc was rather happy that in his absence I was able to take control of the problem. I sent him e-mail - and I said hey doc I got shocked - so I went back on the meds - the wine takes care of the itchies - and oh by the way I got second place in road race a couple days ago.. Meanwhile its only been a week and he hasn't even interrogated my ICD to find out "why" I got shocked. I think I shocked him... He was speechless.. I was happy cause I was back out racing again.

Moral of the story - if your itchy - maybe a little red wine would help !!! it sure put a smile on my face.. :) But as always check with your doctor first..

Marilyn and ****
 
Hi Katie, I'm really sorry if I upset you. I feel just terrible. I decided to go back and find the actual article that I had read it on. Below I've enclosed the message that is posted on The Heart Forum:

Q phoenixdoc
(29-Nov-03) . I was recently diagnosed with moderate (2+) MR. My doc put me on 50mg Atenolol (B-blocker) to help with the discomfort. However, the level of discomfort I am feeling seems out of proportion with the level of MR? Is it normal for moderate levels of MR to cause a lot of chest pain and shortness of breath? And, what is that weird "elevator ride" feeling I get in my chest all the time? He increased my dosage to 50 (was 25) after I had two days of it continuously. I am seeing a cardiologist Monday but was just curious what that was. How do I know when to ignore the chest pain and when to seek care immediately? What is the benefit of b-blockers over ACE inhibitors? Thanks.

------------------------------------------------------------------------------------
CCF-M.D.-RCJ
(29-Nov-03) phoenixdoc phoenixdoc,

Thanks for the post.

Q1:"Is it normal for moderate levels of MR to cause a lot of chest pain and shortness of breath?"

Chest pain is unusual with MR -- but it does depend somewhat on what the pain feels like. If it is a tightness, like that sometimes experienced when a person is short of breath, then it is not totally unusual. Other types of pain should prompt an evaluation for an alternative source of the pain.

Shortness of breath is the chief manifestation of MR in most people. 2+ MR is not often thought of as causing much in the way of symptoms in most people, for that reason 2+ MR is most often referred to as "non-surgical". If you are having a lot of symptoms with 2+ MR then either (1) you are one of the unlucky ones who's symptoms are out-of-proportion to the MR, (2) the MR has been underdiagnosed, or (3) something else explains your symptoms (like coronary artery disease).

Q2:"what is that weird "elevator ride" feeling I get in my chest all the time?"

No idea. I've never heard someone describe this sensation in relation to MR. I'll file it away for the next time someone says this.

Q3:"How do I know when to ignore the chest pain and when to seek care immediately?"

This is the million dollar question. For first-time chest pain sufferers who have not sought attention form a health care provider, I generally tell then to seek attention promptly. The specifics of your chest pain, as well as your previous evaluation will have to dictate when you should seek attention. Certainly any worsening of the pain should prompt evaluation regardless of previous evaluation.

Q4:"What is the benefit of b-blockers over ACE inhibitors?"

In patients with MR, beta-blockers can actually worsen the MR and would not be considered first-line therapy by most cardiologists. ACE-I are considered a temporizing measure to minimize symptoms in patients with symptomatic MR while they await surgery.

Hope that helps.

-------------------------------------------------------------------------------

Katie, The above is the message that I read about the beta blocker. Its posted on The Heart Forum - The website is: www.medhelp.org/per16/cardio/messages/C34364-6.html

I would like to ask the Heart Forum a few questions regarding this - but they only allow two posts per day and I don't think it's Eastern Time because everytime I try to post a message - they are not taking anymore questions. That last paragraph is what upset me.. If you can post a question - please ask him where he got his information about beta blockers and MR. I can't find any other posts that says that. I think its a Cleveland Clinic Website - a well respected doctor - that's why I wanted to do a follow-up. Perhaps I'm misunderstanding his post. Or perhaps it applys to something that doesn't apply to me.. I don't know - I know I was upset when I read it.. as I take a beta blocker and I have MR. So I didn't know what to think and thought I would ask if anyone here on this board has heard of such a thing. Figureing that with alot people with MR here - that they may have been told the same thing by their docs.. I asked several other medical people and they didn't think it was true. I don't know.. I "wish" I could "understand" why the doctor in his message said that about beta blockers and MR. I found it most upsetting and was trying to find some validity to his message.

Good Luck
Take Care
Runner
 
Hi Nancy, thank you for posting. I do understand that beta blockers are a good drug for chest pains - I certainly can't disagree with that statement. I've found that statement on many web sites.. BUT, his last paragraph he states:

"In patients with MR, beta-blockers can actually worsen the MR and would not be considered first-line therapy by most cardiologists. ACE-I are considered a temporizing measure to minimize symptoms in patients with symptomatic MR while they await surgery."

This is the statement that I don't understand. !!!

Was the above paragraph information posted under mitral valve or beta blockers ?? - in your website that you posted previously.

Thanks
Runner
 
The site is a government site which gives info. on medications.

There are statements in the formation re: intolerance to cold, which was one of your concerns. Thought you might catch that.

I didn't see anything about MR per-se, but there is some info about "decreased heart function".

Maybe if you Google beta-blockers and then do a search within the results for MR or mitral regurgitation, you will pull up the information you desire.
 
Thanks Nancy, Yes, I did see that - :) about cold hands and feet. I was most happy - cause then perhaps it wasn't 'menopause' after all !!! Some women at work thought it could be menopause - they get it tooo.. I'm not sure which is better - but since I can't go off my beta blocker - at least I tried and I would never try that again. I'm hoping the cold hands and feet are from 'menopause' and not the meds !!! Of course what I wish for and what I get are two different things.. Several others suggested they had the cold hands and feet 'before' surgery and it went away after surgery. So there's hope for me YET.. Your so nice to follow-up.

Thanks Nancy for your suggestion - I shall do a google search and see if anything pops up.. regarding beta blockers and MR..

Runner :)
 
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