pellicle
Professional Dingbat, Guru and Merkintologist
It came to my attention that (hey @Timmay ) this new fangled thing is causing INR issues
wasn't much on it yet, but I did find an Honours Thesis from the Honors Program of Liberty University in the USA suggesting that this cunning seeding plant has found a new way to poison those animals that it doesn't want eating and distributing its fruit.
Inhibition of Human Cytochrome P450-3A4 isoform by Crude Extracts from Acai Berry
Thesis here.
To be clear you want to keep Cytochrome (that's the CYP) operating properly (its the most important liver enzyme in the disposal of warfarin) to keep your INR and dose response steady.
Wow ... always wonder why people think weird horrible tasting stuff (yes gapefruit I'm looking at you) is healthy rather than horrible?
So there you go, while its early days its one more for the list of "get that stuff out of my food".
This was found by the persson doing regular testing weekly ... which is why I always promote weekly testing.
Best Wishes
wasn't much on it yet, but I did find an Honours Thesis from the Honors Program of Liberty University in the USA suggesting that this cunning seeding plant has found a new way to poison those animals that it doesn't want eating and distributing its fruit.
Inhibition of Human Cytochrome P450-3A4 isoform by Crude Extracts from Acai Berry
The results obtained suggest that compounds in certain acaí fractionations, specifically 94-C (Diosmetin) inhibit the enzymes’ activity by approximately 68%. While further research into the metabolism of acaí berries must be conducted, these results imply that eating acaí berries may be harmful while taking certain medications due to the inability of CYP 3A4 and 2D6 enzymes to adequately metabolize the drug
Thesis here.
To be clear you want to keep Cytochrome (that's the CYP) operating properly (its the most important liver enzyme in the disposal of warfarin) to keep your INR and dose response steady.
Wow ... always wonder why people think weird horrible tasting stuff (yes gapefruit I'm looking at you) is healthy rather than horrible?
So there you go, while its early days its one more for the list of "get that stuff out of my food".
This was found by the persson doing regular testing weekly ... which is why I always promote weekly testing.
Best Wishes