Is an aneurysm common for people with a bicuspid valve?
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Jacque
Member
I had my BAV surgery in 2007, and have been living with a mid ascending aortic aneurysm for 17 1/2 years now. The Mayo Clinic monitors me and they said the magic number is 5.5 cm (about 2") now; I’m at a 4 cm (about 1.5").
I stay pretty active and I am thankful and grateful for that; I work out, play Pickleball, bicycle, hike, lift my grandkiddos…
Factoid: With an aneurysm one should avoid a class of antibiotics known as fluoroquinolones: Cipro (ciprofloxacin), Levaquin (levofloxacin), Factive (gemifloxacin) and Avelox (moxifloxacin). These medications may increase the risk of aortic dissections or ruptures.
Blessings to you all!
pellicle
Professional Dingbat, Guru and Merkintologist
interesting ... thanks for that
January 6, 2021
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Subgroup Analyses
When stratified by age, the association of fluoroquinolones with aneurysm was significantly different across age groups (18-34 years: HR, 0.99; 95% CI, 0.83-1.18; 35-49 years: HR, 1.18; 95% CI, 1.09-1.28; 50-64 years: HR, 1.24; 95% CI, 1.19-1.28; P = .04) (eFigure 3 in the Supplement). Minimal differences were seen when stratified by sex, diabetes, hypertension, and hyperlipidemia (Figure 4; eFigures 4, 5, 6, and 7 in the Supplement). These data collectively suggested that fluoroquinolone use was associated with an increased risk of aneurysm among all adults aged 35 years or older and that other traditional risk factors, such as sex and comorbidities, may also be associated with aneurysm among adults, although the association may be minimal.
Conclusions
In conclusion, fluoroquinolone use in the US and internationally has been associated with an increase in immediate incidence of aortic aneurysm formation. Although the overall incidence of aneurysm formation detected in the present study was low, the aneurysm incidence after a fluoroquinolone fill was 20% higher than that of comparator antibiotics, and consistent among all adults age 35 years or older. When examining specific anatomic sites, there was a 31% higher incidence of abdominal aortic aneurysm and a 60% higher incidence of iliac artery aneurysm after fluoroquinolone use. Contextualizing these data, we believe that the current US FDA black box warnings are warranted but may need to be expanded to include younger adults with other risk factors. Further studies will be needed to elucidate the mechanisms of fluoroquinolone-associated aneurysm development in humans in addition to studies that evaluate risk in the setting of known risk factors for aneurysmal disease or worse health care outcomes.
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Often times there are no symptoms for aotic aneurysm, which is why it is important to get follow up echos or CT scans to monitor its size. As it gets larger, the frequency of the follow ups should be increased.
Below is a link which indicates some common symptoms, but don't make the mistake of thinking that because you are not experiencing symptoms that all is well. Make sure to get those follow up appointments.
https://www.nhlbi.nih.gov/health/aortic-aneurysm/symptoms
WeirsGuy
Member
Did you get a tissue or mechanical valve in 2007? Thanks
