What is the cause of calcified AS in tri cuspid patients, especially younger ones ? For me I think genetics, high lipoprotein, genetically low levels of HDL, NOT following a low fat plant based diet sience childhood, heart disease which runs in my family, high blood pressure, a heart Un healthy diet ? But at the end of the day the mechanisms of aortic valve disease see to be pretty misunderstood therefore there is no treatment to slow down reverse or cure the disease.