Good to know.
For the few here who may take Plavix: Plavix doesn't go well with Prilosec or other proton-pump inhibitors. These include: omeprazole (Prilosec), lansoprazole (Prevacid), rabeprazole (Aciphex), pantoprazole (Protonix), esomeprazole (Nexium), and Zegarid. They use the same chemical route to exit the body, and there's not enough of the chemical to let them both out through the liver at the proper rate. Talk to your doctor if you are on Plavix and want to use serious antacids.
Also be aware that these acid reducers can increase the concentration of digoxin (Lanoxin) in the blood and can increase INR (especially Prilosec) for those using warfarin. Those on digoxin should discuss the use of any of these with their doctors or pharmacists. Those on warfarin would just monitor and adjust for it, if needed.
There are also side effects from these drugs with long-term or nearly continuous use. That's what's obviously being pushed here, despite the instructions on the package about only using them for very limited periods of time (14 days at a time, up to three times per year). Based on the instructions for OTC use, one 42-count box of Prilosec is a year's supply - but you must buy two for the rebate.
The FDA has issued warnings for long-term use (over a year) or higher dosages of Proton Pump inhibitors for increased danger of fractures of the spine, hip, and wrist, and possible increased rate of infection by clostridium difficile, a bacterium that is hard to get rid of and causes severe diarrhea.
It's tough to stop taking them after 14 days, because they work so well (I use them, too). However, as with any drug, you should get up-to-date on their evil side, so you know what to keep an eye out for. The fact that some of them are now being sold OTC (over the counter) doesn't make any of them less serious drugs or their possible ill effects any less.
Best wishes,