Joe Cool
Well-known member
I would like to know of those of you who take anti-platelet medication which you take.
Thanks.
Thanks.
Poll: Do you take asprin or Plavix
- Thread starter Joe Cool
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Ross
Well-known member
When I first got out after surgery I was taking asprin, plavix and Coumadin. Plavix and I don't play nice together. I start coughing up blood while on it, so it was discontinued for me.
Aspirin, Plavix, and Coumadin? Together?Ross said:
Why didn't you just swallow razor blades?
This poll may be weighted by the fact that most people over 50 are simply told to take aspirin if they're not on any other ACT. And many are being put on Plavix (clopidegrel) for just a few months after surgery for stroke avoidance, so they may not be permanent.
Best wishes,
Ross
Well-known member
Hey Plavix was brand new and touted highly by surgeons. Why not put me on all of them? No never mind I have bleeding lungs anyway right?
S
Susan BAV
What reasons would a person be on Plavix instead of Aspirin or Coumadin/Warfarin; and for which might it usually be substituted?
Is it usually taken alone, without being combined with other forms of ACT?
Could a person be put on Plavix as a permanent form of ACT or would it likely be a temporary thing, like Lovenox and Heparin are usually temporary?
Is there any reference information here on the various ACT options, or a "Sticky Thread" in regard to such?
Is it usually taken alone, without being combined with other forms of ACT?
Could a person be put on Plavix as a permanent form of ACT or would it likely be a temporary thing, like Lovenox and Heparin are usually temporary?
Is there any reference information here on the various ACT options, or a "Sticky Thread" in regard to such?
Ross
Well-known member
I'll attempt to answer this one.
Plavix works on blood platelets differently from Warfarin or asprin, though it works very closely to asprin.
It has been combined for some people along with Warfarin and asprin.
Plavix is supposed to help stop the formation of plaque in arteries and is usually prescribed permanently. It's not meant to be a substitute for anything, but On-X is using it in the trials.
No stickie threads for it because valve patients don't have a choice in anticoagulation. It's Warfarin and that's it. On-X trials may prove in the future something differnent, but for now, Warfarin is it.
See Al's article here:
http://www.warfarinfo.com/warfasaclop.htm
These may help you out too:
http://www.warfarinfo.com/aspirin-warfarin.htm
http://www.warfarinfo.com/aspirinwithwarfarin.htm
http://www.warfarinfo.com/warfarin-platelets.htm
Clopidegrel (Plavix) is being used long-term for some types of ACT use, such as AFib, but specifically not for valves. It doesn't work for mechanical valves because it doesn't have the right activity, and won't properly protect against the type of clots mechanical valves can produce.
However, there are at least two, new anticoagulants from different companies that are now in clinical trials for long-term ACT for atrial fibrillation. Three I know of are being readied for the short-term use market, once their clinical trials are concluded: Bayer's Rivaroxaban, Boehringer Ingelheim’s Pradaxa, and Bristol-Myers Squibb’s Apixaban. They have a different action from clopidegrel or warfarin, but with a result similar to warfarin's, and any of these would have some possibility of becoming a replacement for warfarin (Coumadin) for valves eventually. If proven safe in the AFib trials, they will undoubtedly be clinical-trialed for the valve ACT market right afterwards. If successful, the benefit could be a once-a-day ACT pill without INR testing.
There are some liver enzymes that become slightly raised with these drugs, but there is no current evidence that this level of rise causes harm, even over time. This is noteworthy, because a third, similar ACT drug, which was trialed earlier, raised enzymes much higher, and eventually failed clinical trials when it was determined that it did present a possible threat of liver damage over time.
Best wishes,
However, there are at least two, new anticoagulants from different companies that are now in clinical trials for long-term ACT for atrial fibrillation. Three I know of are being readied for the short-term use market, once their clinical trials are concluded: Bayer's Rivaroxaban, Boehringer Ingelheim’s Pradaxa, and Bristol-Myers Squibb’s Apixaban. They have a different action from clopidegrel or warfarin, but with a result similar to warfarin's, and any of these would have some possibility of becoming a replacement for warfarin (Coumadin) for valves eventually. If proven safe in the AFib trials, they will undoubtedly be clinical-trialed for the valve ACT market right afterwards. If successful, the benefit could be a once-a-day ACT pill without INR testing.
There are some liver enzymes that become slightly raised with these drugs, but there is no current evidence that this level of rise causes harm, even over time. This is noteworthy, because a third, similar ACT drug, which was trialed earlier, raised enzymes much higher, and eventually failed clinical trials when it was determined that it did present a possible threat of liver damage over time.
Best wishes,
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