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Cerebrovasc Dis. 2005 Apr 8;19(5):337-342 [Epub ahead of print]
Withdrawal of Warfarin prior to a Surgical Procedure: Time to Follow the Guidelines?
Akopov SE, Suzuki S, Fredieu A, Kidwell CS, Saver JL, Cohen SN. Division of Neurology, Cedars-Sinai Medical Center Los Angeles, Los Angeles, Calif., USA.
Background and Objective: Patients with cardiogenic sources of embolism may be at increased risk of cerebral infarction when anticoagulation therapy is suspended for surgical procedures. The purpose of this study was to determine frequency of cardioembolic cerebral infarction during periprocedural warfarin withdrawal. Methods: Retrospective analysis of prospective cerebral infarction registry data from two tertiary medical centers. Results: Over a 12-month period, 14 cases of cardioembolic cerebral infarction occurring during the period of warfarin withdrawal for a medical procedure were observed, accounting for 7.1% of the 197 cardioembolic cerebral infarctions encountered. Across all patients, cerebral infarctions developed an average of 5.4 days after the last dose of warfarin (range 3-8). Among the 14 patients (8 males and 6 females) with warfarin cessation-related infarcts, age ranged from 54 to 91 years. Each had been on chronic anticoagulation with warfarin for more than 1 year. Retrospective analysis suggested that all these cerebral infarctions had been potentially preventable. In each case, either the planned procedure did not require discontinuation of warfarin or, when withdrawal was required, no bridging, parenteral anticoagulation was provided to lessen the risk during the warfarin-free period. Conclusion: Patients at high risk of cardioembolic cerebral infarction may benefit from more intensive management strategies to reduce cerebral infarction risk during periprocedural periods. Copyright (c) 2005 S. Karger AG, Basel.
The sad part is that the title asks a question.
We've tapped on the door.
We've knocked on the door.
We've banged on the door.
Now it's time to kick the door down.
Withdrawal of Warfarin prior to a Surgical Procedure: Time to Follow the Guidelines?
Akopov SE, Suzuki S, Fredieu A, Kidwell CS, Saver JL, Cohen SN. Division of Neurology, Cedars-Sinai Medical Center Los Angeles, Los Angeles, Calif., USA.
Background and Objective: Patients with cardiogenic sources of embolism may be at increased risk of cerebral infarction when anticoagulation therapy is suspended for surgical procedures. The purpose of this study was to determine frequency of cardioembolic cerebral infarction during periprocedural warfarin withdrawal. Methods: Retrospective analysis of prospective cerebral infarction registry data from two tertiary medical centers. Results: Over a 12-month period, 14 cases of cardioembolic cerebral infarction occurring during the period of warfarin withdrawal for a medical procedure were observed, accounting for 7.1% of the 197 cardioembolic cerebral infarctions encountered. Across all patients, cerebral infarctions developed an average of 5.4 days after the last dose of warfarin (range 3-8). Among the 14 patients (8 males and 6 females) with warfarin cessation-related infarcts, age ranged from 54 to 91 years. Each had been on chronic anticoagulation with warfarin for more than 1 year. Retrospective analysis suggested that all these cerebral infarctions had been potentially preventable. In each case, either the planned procedure did not require discontinuation of warfarin or, when withdrawal was required, no bridging, parenteral anticoagulation was provided to lessen the risk during the warfarin-free period. Conclusion: Patients at high risk of cardioembolic cerebral infarction may benefit from more intensive management strategies to reduce cerebral infarction risk during periprocedural periods. Copyright (c) 2005 S. Karger AG, Basel.
The sad part is that the title asks a question.
We've tapped on the door.
We've knocked on the door.
We've banged on the door.
Now it's time to kick the door down.