Grapefruit

[Zoeey2011]

Does anyone know if grapefruit interacts with warfarin?

 

[pellicle]

Does anyone know if grapefruit interacts with warfarin?

yes, it does
https://www.valvereplacement.org/threads/my-monty-python-moment.42094/

you will need (by testing) to identify how much is needed and in the way you intend to use it influences your INR

myself I avoid that sour crap that needs its weight in sugar to make it palatable (YMMV)

 

[dick0236]

I ate grapefruit long before it was put on the "no-no" list and still do a few times each month. I've never seen a change in my INR that I could attribute to grapefruit. That said, I have heard that drinking a large quantity of grapefruit JUICE will affect AC. I seldom, if ever, drink more than a glass of juice or eat more than 1/2 grapefruit.

 

[Eva]

Grapefruit, in general, lessens the effect of most medications!
I still eat a few now and then at around midday to somehow avoid it’s worst effect which is at its highest within two hours of its consumption.
You need to test to see how it affects your INR!

 

[Protimenow]

I avoid grapefruit, in part because I don't like it much anyway.
One thing I should mention is that if you have a sensitive stomach already, and it causes gastric irritation or bleeding, being on Warfarin could make the bleeding take longer to stop.

 

[carolinemc]

It is something the grapefruit that lessens the effects of Warafrin(Coumadin), this also includes Green tea. So always when in doubt, talk to your cardio about your diet and any changes you wish to make.

 

[pellicle]

It is something the grapefruit that lessens the effects of Warafrin(Coumadin),

this may help
https://www.drugs.com/article/grapefruit-drug-interactions.html

Grapefruit juice decreases the activity of the cytochrome P450 3A4 (CYP3A4) enzymes that are responsible for breaking down many drugs and toxins. Grapefruit contains compounds known as furanocoumarins that block the CYP3A4 enzymes. When grapefruit juice is consumed, the enzyme’s ability to break down the drug for elimination is decreased. Blood levels of the drug may rise, resulting in the risk for new or worsened side effects.​

so basically good old P450 again ;-)

 

[carolinemc]

.

 

[carolinemc]

this may help
https://www.drugs.com/article/grapefruit-drug-interactions.html

Grapefruit juice decreases the activity of the cytochrome P450 3A4 (CYP3A4) enzymes that are responsible for breaking down many drugs and toxins. Grapefruit contains compounds known as furanocoumarins that block the CYP3A4 enzymes. When grapefruit juice is consumed, the enzyme’s ability to break down the drug for elimination is decreased. Blood levels of the drug may rise, resulting in the risk for new or worsened side effects.​

so basically good old P450 again ;-)

And stay away from Green tea also, it affects the way warafrin works.

 

[W. Carter]

Every time I have drank too much grapefruit juice I will pee blood the next morning. Same with tomatoe juice. Quit drinking it and urine clears up. So yes it does. I just quit trying to drink either.

 

[almost_hectic]

And stay away from Green tea also, it affects the way warafrin works.

I drink loads of green tea, it has zero effect on my INR

 

[Protimenow]

This article has good, well researched information on interactions, likely interactions, and combinations that probably have no interactions. Grapefruit, fermented soy (and other soy products), and cranberries are all to be carefully watched or avoided. https://www.hindawi.com/journals/ecam/2014/957362/.

This table is even easier to understand: https://www.hindawi.com/journals/ecam/2014/957362/tab3/

 

[tom in MO]

First thing listed on the table is cranberry listed as severity:major. I looked into this a few years ago since I like cranberries. I found out that it was not well founded. The warning for cranberries appears to trace back to a few instances of intense cranberry juice drinking and speculation. I have a glass of cranberry juice about 2 times a week with no problems and also eat cranberry backed products.

Cannabis is also listed as severity:major. There's a lot of people on warfarin that smoke and eat pot.

I wouldn't put much faith in that reference.