I have taken Glucosamine Condroiten for several years. About two months before my surgery when I went into A-Fib, I was put on Coumadin (among other things including Amiodarone). At that time, I stopped taking certain supplements like the Glucosamine Condroiten. After my surgery, I was on Coumadin for almost a year since my cardio was concerned about my fast heart rate (which was much faster when I went to see him - white-coat syndrome). In any case, a few months after my surgery (still on Coumadin), I started back on the Glucosamine Condroiten. It didn't seem to affect my INR. Amiodarone was the only thing which really affected my INR. Once that was out of my system, I was very stable.