genetics/pregnancy questions...

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H

Harpoon

Afternooon (for some),


Been a while, I know, but I've been busy, REAL busy, too busy to get into all the details really although you may have recently seen a photo of mine in the New York Times if you live there, New York City I mean.

It wasn't in the national edition.

Anyways...

My wife and I recently found out "we" were pregnant and less than 48 hours later found out she was miscarrying. it's been a real rough ride that's not quite over yet.

This is the second time it's happened, the last was three years ago and that wasn't something we "planned on."

This time wasn't exactly planned, but we weren't trying to avoid it either and it's been harder because we were actually excited about the prospects of having a second child.

My question is this: Given all the medications I'm on, given the nature of my congenital heart defect and also what I went through when I had my tricuspid valve replaced in 2003, is it possible that my genes (or whatever) aren't viable for child producing???

Mind you, I'm very familiar with the biology of the question and how genetics work. I know medications and surgery don't generally effect genetics and most people that have OHS go on to have plenty of healthy babies and the like.

However, I have a very specific form of heart defect, Transposition of the Great Vessels, and I know that in many cases, it may have a genetic origin either a hereditary glitch or abnormality or a trait that could potentially be based on generation to generation.

There is absolutely NO known history of congenital heart defects in either side of my family. Same with my wife.

However, there are a lot of lingering questions at the moment and I wouldn't mind hearing some opinions on the matter.

Oh, and I'm WELL aware that my condition has relevance to maybe .00538% of the membership here who have congenital heart defects. :D

Quick updates here: I'm still a reporter for the paper (not a photographer any more, though I still shoot quite a bit, now I have a full time position)

I'm still a firefighter/EMT and I've been working on getting myself a job with the local ambulance service. I get a fair number of calls and it's been a blast.

We've still got the house, we're still renovating, we haven't moved in yet, hopefully before the white stuff starts flying... Mostly working on remodeling a bathroom, painting, and finishing a ramp.
Oh, and window replacements...

I'll be around... Thanks.
 
I am very sorry for your loss. as for the question i am sure genetics plays a part in CHD, since my brothers lost a child to TGa and Justin has it AND my husbands brother passed from heart surgery at 12 AND his great niece has TOF, but I'm not really sure how much of a role it plays. but some CHd occure more frequetly in families than others from what i understand.
I don't rember if you are a member of the adult w/ chd forum, but they talk about pregnancy ect quite often and have all the stats ect, maybe you could post this question there.
about your picture is there a link online to see it? do you live right in manhatten? we are going up for the day on friday, ooops I see you live in western NY, Lyn
 
sorry I was just wonderring if you have ever gone to a genetic doc? I know alot of CHd adults have maybe they could help you Lyn
 
Hiya,
I know the condition TGA (or V) quite well - have several friends with children who have it, none of whom that I know of have any genetic link that caused it and some have had tests too check that. But I wouldnt know about the fathering bit - have you tried the grown up congential heart patient website? Its an british one but has a very good message board and Im sure there are people on there who have asked this question and will be able to answer it for you.

Its

www.guch.org.uk

Love Emma
xxx
 
I don't live in NYC, just had a photo published in the Times...

It was a "freelance" photo assignment.
 
Hello - you have been on my mind just lately, wondrin how you two are. I am so sorry you have lost this child. My thoughts are with you.

There is a new member who told his story in the last couple of days, but I can't recall his name just now. He said when he was choosing his valve, he chose Ross valve because he 'wanted to have children' some time in the future. He had his surg at a young age. His first post was titled ' do y'all really meet' or something close to that. Find that post, then look up all his posts. Maybe he has an answer for you.

Wishing you and your wife all the best.
 
Harpoon:

I am so very sorry about this. How far along were both of these pregnancies when they were lost?
My niece's sister-in-law went through this -- several miscarriages. Because she's a Vietnamese adopted by a couple in the U.S., she knows nothing about her family medical history, only her husband's.
She FINALLY carried a baby to term, well, 3 weeks short of term and delivered a healthy baby last Saturday (8/5). My nephew-in-law's family was ecstatic.
I don't know what she did differently this time to prevent miscarriages; I do know her doctor did one procedure to prevent an premature birth.

You might ask the doctors about hormone imbalances, any minor uterine infections.
 
Once everything is settled and my wife is ready to try again, we'll be talking to our doctors and get as much as we can in order before moving forward.

I had my 6 month check-up and echo yesterday (Wednesday) with my cardiologist and he was nothing but smiles. Good stuff. Also had a new tech doing the echo. She was really nice, very little experience with congenital heart defects, I was her first "Mustard" ever and she had a lot of fun trying to visualize all my unique heart characteristics, especially the baffle which is one of the key characteristics of the Mustard (and Senning) proceedure...

I even got to watch my cardiologist sketch out the baffle and associated physiology on a sheet of notepaper for her. I never knew he could draw that well!

Anyways, all's fine and we got to talking about the possibility that my heart condition (and genetics) mighth ave something to do with the two miscarraiges.

He suspects not. He pointed out that, in utero, we are all creatures with 3 chambered hearts and we live just fine that way just like most aquatic life on the planet. It's only when we start breathing air that that fourth chamber becomes REALLY important to sustaining life.

As such, nearly all forms of congenital heart defects survive just fine through nine months of gestation, it's only until the baby is born that problems start to develope so our pregnancy shouldn't have experienced problems because of my heart condition.

He said there's MAYBE a 4 percent chances that I could pass on a heart condition to my child, about double any other person's chance. So in terms of probablity, if I had 100 babies, four MIGHT have a heart condition.

Anyways, he thought it unlikely that my codition would have contributed to a miscarraige or that I would pass on a heart condition.
 
Glad everything is looking so good and hope you and your wife are doing a little better emotionally after such a loss.
Do you go to a clinic/cardiologist that specializes in Adults w/ CHD? I was just wonderring since it is just relatively recently that there are such clinic, and it seemed funny the echo tech never saw a "mustard' before
good luck w/ everything and keep in touch, lyn
 

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