Drug Question???

[Cooker]

My PP has started me on diclofenac (Cataflam) on an as needed basis. It has done wonders for muscle and joint pain. I hardly ever need more than one a day.

Does anyone know if this could have an effect on INR or cause bleeding problems?

Thanks,

Tom

 

[Ross]

http://www.drugdigest.org/DD/Interaction/ChooseDrugs/1,4109,,00.html

WARFARIN SODIUM (in Coumadin) may interact with DICLOFENAC

Blood clotting normally occurs in response to a cut or other types of injuries to protect the body from excessive bleeding. Platelets, a type of cell found in the blood, are involved in helping the blood to clot when it is needed. Diclofenac may interfere with the platelets' ability to work properly. It may also damage the lining of the stomach, particularly when used for a long period of time, and this may increase the risk of developing a bleeding ulcer. Warfarin is generally used to prevent your blood from "coagulating" or forming blood clots. When diclofenac and warfarin are used at the same time, your blood may be much less likely to clot and this may increase the risk of excessive bleeding. If it is necessary to use diclofenac while you are taking warfarin, your doctor may want to monitor you closely for signs of bleeding. Let your doctor know if your bowel movements appear black or tarry, or if you are having any stomach pain. Blood tests can be used to make sure that you are getting the right amount of warfarin. If you are experiencing problems, it may be necessary to adjust the dose of warfarin. Your doctor may also consider stopping therapy with diclofenac. Ask your healthcare provider about these drugs and this potential interaction as soon as possible.

This interaction is well-documented and is considered major in severity.

Last Updated: April 2006

 

[Troy]

My family doctor recommended that I take Lodine, (Etodolac) for joint pain, my cardio said it was ok but watch for bleeding. Any idea what it will do to my INR? I haven't started it yet. The pharmacist was pretty concerned about me taking Lodine (500mg) with asprin and Coumadin.

 

[PJmomrunner]

http://www.drugdigest.org/DD/Intera...&dN="Aspirin"+"Coumadin"+"Lodine"+&CheckFDA=1

ASPIRIN may interact with ETODOLAC (in Lodine)

Etodolac is broken down by the liver and removed from the body in the urine. If this happens too quickly, then potentially less etodolac would be available for the body to use and blood levels could become too low. This could make etodolac less effective. Aspirin may cause etodolac to be broken down at a faster rate than normal. Based on information from a number of studies, this does not appear to have a significant impact on the therapeutic effect of etodolac. However, both of these drugs can cause stomach irritation and may potentially damage the lining of the stomach. The risk of experiencing these side effects may be increased when aspirin and etodolac are taken at the same time. You may want to ask your healthcare provider about this potential interaction if you think you are having problems.

This interaction is poorly documented and is considered minor in severity.

Last Updated: May 2004



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ETODOLAC (in Lodine) may interact with WARFARIN SODIUM (in Coumadin)

Blood clotting normally occurs in response to a cut or other types of injuries to protect the body from excessive bleeding. Platelets, a type of cell found in the blood, are involved in helping the blood to clot when it is needed. Etodolac may interfere with the platelets' ability to work properly. It may also damage the lining of the stomach, particularly when used for a long period of time, and this may increase the risk of developing a bleeding ulcer. Warfarin is generally used to prevent your blood from "coagulating" or forming blood clots. When etodolac and warfarin are used at the same time, your blood may be much less likely to clot and this may increase the risk of excessive bleeding. If it is necessary to use etodolac while you are taking warfarin, your doctor may want to monitor you closely for signs of bleeding. Let your doctor know if your bowel movements appear black or tarry, or if you are having any stomach pain. Blood tests can be used to make sure that you are getting the right amount of warfarin. If you are experiencing problems, it may be necessary to adjust the dose of warfarin. Your doctor may also consider stopping therapy with etodolac. Ask your healthcare provider about these drugs and this potential interaction as soon as possible.

This interaction is well-documented and is considered major in severity.

Last Updated: April 2006

 

[Ross]

My family doctor recommended that I take Lodine, (Etodolac) for joint pain, my cardio said it was ok but watch for bleeding. Any idea what it will do to my INR? I haven't started it yet. The pharmacist was pretty concerned about me taking Lodine (500mg) with asprin and Coumadin.

What drug(s) may interact with etodolac? (Back to top)
?ACE inhibitors, often used to treat high blood pressure or heart problems
?agents that treat or prevent blood clots such as warfarin or other 'blood thinners'
?agents that affect platelets
?alcohol
?alendronate
?aspirin and aspirin-like medicines
?cyclosporine
?drospirenone; ethinyl estradiol (Yasmin®)
?entecavir
?herbal products that contain feverfew, garlic, ginger, or ginkgo biloba
?lithium
?methotrexate
?other antiinflammatory drugs (such as ibuprofen or prednisone)
?pemetrexed
?water pills (diuretics)

Tell your prescriber or health care professional about all other medicines you are taking, including non-prescription medicines, nutritional supplements, or herbal products. Also tell your prescriber or health care professional if you are a frequent user of drinks with caffeine or alcohol, if you smoke, or if you use illegal drugs. These may affect the way your medicine works. Check with your health care professional before stopping or starting any of your medicines.

 

[Guest]

This is another one like naproxen. There is not even one report of anyone ever being harmed by this combination but because it is similar to ibuprofen it gets tagged by the FDA as a bad guy. It is like going to jail for something that your cousin did.

 

[ALCapshaw2]

Hey Tom,

Did you receive the e-mail I sent through VR.com some time ago?

I'd like to know how Sheila2old is doing and if she would be willing to take a phone call from me to discuss radiation effects on her recovery.

Please respond via e-mail through VR.com if that is acceptable to you. (My private mail box is full)

'AL Capshaw'