Drug interaction between Oxandrin & Warfarin

[Dee]

I just received this e-mail from the FDA about an important drug interaction between Oxandrin and warfarin. Please read if you're on Oxandrin! Also, to subscribe to the free e-mails from the FDA on medical device recalls and drug information click on the link below. I think everyone should get this!

http://list.nih.gov/cgi-bin/wa?SUBED1=medwatch&A=1

Here's the notice:

MedWatch - The FDA Safety Information and Adverse Event Reporting Program

Savient Pharmaceuticals, Inc. notified healthcare professionals of an
important drug interaction between Oxandrin, a synthetic derivative of
testosterone, and the oral anticoagulant warfarin for systemic
anticoagulation. Oxandrin is indicated as adjunctive therapy to promote
weight gain and for the relief of the bone pain frequently accompanying
osteoporosis. Concurrent dosing of Oxandrin and warfarin may result in
unexpectedly large increases in the International Normalized Ratio (INR) or
prothrombin time (PT). When Oxandrin is prescribed to patients being treated
with warfarin, doses of warfarin may need to be decreased significantly to
maintain a desirable INR level and diminish the risk of potentially serious
bleeding.

http://www.fda.gov/medwatch/SAFETY/2004/safety04.htm#oxandrin

~DeeDee~

 

[Ross]

ah ha someone beat me to posting this.

 

[Guest]

I have not received my letter yet.

That is a pretty important dose decrease 6 to 1 mg per day.

It has not been reported yet in any medical journals.

Some of the older testosterone products were reported to do this but I couldn't find where they actually caused any harm to anyone.

However, requiring a dose change of this magnitude could result in harm.