Depakote, lamotrigine, trileptal, and lyrica

[Jackie]

Does anyone know how these drugs affect INR?

Depakote, lamotrigine, trileptal, and lyrica

 

[Guest]

I have never seens reports of interactions.

 

[Jackie]

I have never seens reports of interactions.

Thank you Al

 

[LaughClown]

I was looking through the newest physicians desk reference guide a couple weeks ago and I am pretty certain they mention depakote. I was on it a few yrs ago so it stood out to me. They may have mentioned lamotragine (which Ive also taken) but i couldnt say for sure. of course, they mention everything underthe sun.
Id at least look into it. And frankly if you gorra be on it, then you gotta be on it. Adjust inr after imo

 

[Lisa in Katy]

I know that when my mom took Depakote she had to have her platelets monitored because it could lower them. If it can affect the platelets, it seems that it would affect the body's ability to clot.

I found this online. Depakote in the brand name of valproic acid.

Valproic acid can reduce the number of platelets or inhibit the ability of platelets to stick together and form a blood clot. Therefore, it may exaggerate the effects of other medications which inhibit the stickiness of platelets or inhibit other steps in the clotting of blood. This can lead to abnormal bleeding due to the inability of blood to clot. Such medications include warfarin (Coumadin), heparin or low-molecular weight heparin (Lovenox), clopidogrel (Plavix), ticlopidine (Ticlid), and nonsteroidal antiinflammatory drugs (NSAIDs) such as ibuprofen (Motrin, Advil), naproxen (Naprosyn, Aleve), indomethacin (Indocin), nabumetone (Relafen), diclofenac (Voltaren, Cataflam, Arthrotec), ketorolac (Toradol) and aspirin.

 

[Jackie]

I know that when my mom took Depakote she had to have her platelets monitored because it could lower them. If it can affect the platelets, it seems that it would affect the body's ability to clot.

I found this online. Depakote in the brand name of valproic acid.

Valproic acid can reduce the number of platelets or inhibit the ability of platelets to stick together and form a blood clot. Therefore, it may exaggerate the effects of other medications which inhibit the stickiness of platelets or inhibit other steps in the clotting of blood. This can lead to abnormal bleeding due to the inability of blood to clot. Such medications include warfarin (Coumadin), heparin or low-molecular weight heparin (Lovenox), clopidogrel (Plavix), ticlopidine (Ticlid), and nonsteroidal antiinflammatory drugs (NSAIDs) such as ibuprofen (Motrin, Advil), naproxen (Naprosyn, Aleve), indomethacin (Indocin), nabumetone (Relafen), diclofenac (Voltaren, Cataflam, Arthrotec), ketorolac (Toradol) and aspirin.

Thank you Lisa, I think I will just stop taking all nerve meds and tell my myself that the pain in my feet just isn't there and I can sleep. I have stoped taking Zocor so will see if that has any inpact.I have a note into my Cardo to see if she approves any of the meds the Neuroligist recommended. Have not heard anything yet.