PS:
did some further readings:
About the product (
here):
CryoFreeze roll on is a topical cooling cream that comes in a hands-free roll-on. The paraben free cream contains Cannabidiol (CBD), Menthol, ...
this publication (
found here):
Characterization of Cytochrome P450 3A Inactivation by Cannabidiol: Possible Involvement of
Cannabidiol-Hydroxyquinone as a
P450 Inactivator
Department of Cellular and Molecular Pharmacology and Liver Center and Department of Biopharmaceutical Sciences, University of California, San Francisco, California 94143-0450 Received March 27, 1998
C Orthologues of these P450s are also found in human liver microsomes, and CBD can inactivate human P450 3A4, which is responsible for metabolizing more than 60% of clinically prescribed drugs....
further this article clarifies that there may indeed be something in CYP3A ...
https://www.ingentaconnect.com/content/ben/dml/2010/00000004/00000004/art00004
Effective Coumadin (R/S-warfarin) therapy is complicated by inter-individual variability in metabolism. Recent studies have demonstrated that CYP3A isoforms likely contribute to patient responses and clinical outcomes. Despite a significant focus on CYP3A4, little is known about CYP3A5 and CYP3A7 metabolism of warfarin. Based on our studies, recombinant CYP3A4, CYP3A5 and CYP3A7 metabolized R- and S-warfarin to 10- and 4'-hydroxywarfarin with efficiencies that depended on the individual enzymes. For R-warfarin, CYP3A4, CYP3A7, and CYP3A5 demonstrated decreasing preference for 10-hydroxylation over 4'-hydroxylation. By contrast, there was no regioselectivity toward Swarfarin. While all enzymes preferentially metabolized R-warfarin, CYP3A4 was the most efficient at metabolizing all reactions. Individuals, namely African-Americans and children, with higher relative levels of CYP3A5 and/or CYP3A7, respectively, compared to CYP3A4 may metabolize warfarin less efficiently and thus may require lower doses and be at risk for adverse drug-drug interactions related to the contributions of the respective enzymes.
importantly (from MIMS):
| The clearance of R-warfarin is generally half that of S-warfarin, thus as the volumes of distribution are similar, the half-life of R-warfarin is longer than that of S-warfarin. The half-life of R-warfarin ranges from 37 to 89 hours, while that of S-warfarin ranges from 21 to 43 hours. |
however since S warfarin is five times more potent an anticoagulant than R warfarin (
citation) its probably not going to be significant. So there maybe a case that it could increase your INR by interaction with that metabolism pathway.
As always, I go back to "test and know thyself" as my personal recommendation.
I never do understand why everyone on warfarin who is of sound mind is not self testing (and preferably self managing.
Best Wishes
.
